Buonocore Daniela, Rucci Sara, Vandoni Matteo, Negro Massimo, Marzatico Fulvio
Laboratory of Pharmaco-biochemistry, Nutrition and Nutraceutics of Wellness, University of Pavia, Italy.
Muscles Ligaments Tendons J. 2012 Feb 15;1(3):85-90. Print 2011 Jul.
Aging is an inevitable biological process that is characterized by a general decline in the physiological and biochemical functions of the major systems. In the case of the neuromuscular system, reductions in strength and mobility cause a deterioration in motor performance, impaired mobility and disability. At the cellular level, aging is caused by a progressive decline in mitochondrial function that results in the accumulation of reactive oxygen species (ROS). As the level of oxidative stress in skeletal muscle increases with age, the age-process is characterized by an imbalance between an increase in ROS production in the organism, and antioxidant defences as a whole. We have reviewed the literature on oxidative stress in aging human skeletal muscles, and to assesss the impact of differences in physiological factors (sex, fiber composition, muscle type and function).
衰老 是一个不可避免的生物学过程，其特征是主要系统的生理和生化功能普遍下降。就神经肌肉系统而言，力量和活动能力的降低会导致运动表现恶化、活动能力受损和残疾。在细胞水平上，衰老是由线粒体功能的逐渐下降引起的，这会导致活性氧（ROS）的积累。随着骨骼肌中氧化应激水平随年龄增长而增加，衰老过程的特征是机体中ROS产生的增加与整体抗氧化防御之间的失衡。我们回顾了关于衰老人类骨骼肌氧化应激的文献，并评估了生理因素（性别、纤维组成、肌肉类型和功能）差异的影响。
