Department of Biological Sciences, University of Bamenda, Bambili, Cameroon.
Pharm Biol. 2013 Aug;51(8):1014-20. doi: 10.3109/13880209.2013.774029. Epub 2013 Jun 5.
Medicinal plants have become a great source of relief for more 70% of the population in developing countries where access to modern medicine is very limited. Some of these plants are used as aphrodisiac agents. The stem bark of Allanblackia floribunda Oliver (Clusiacea) has been used in Cameroon as an aphrodisiac.
This study was designed to assess the effects of Allanblackia floribunda aqueous and ethanol extracts and their potential mechanism on fictive ejaculation in spinal male rats.
Electromyographic activities of the bulbospongiosus muscles were recorded in 24 groups of spinal rats after intravenous administration of aqueous and ethanol extracts (2.5, 10, 20, 40 or 60 mg/kg) from the stem bark of A. floribunda in the presence or absence of dopamine (60 mg/kg). Furthermore, electromyographic activities of the bulbospongiosus muscles were recorded in five groups of spinal rats pre-treated orally during 8 d with extracts (150 and 300 mg/kg) in the presence of dopamine.
Sequential treatments of rats with extracts significantly decreased the occurrence of ejaculation induced by dopamine up to 88.94% inhibition. The oral pre-treatment with both extracts significantly decreased the ejaculation induced by dopamine with the highest inhibition of 89.79%.
Two extracts of A. floribunda used in this study had inhibitory activities on ejaculation. The inhibitory effect of A. floribunda extracts on fictive ejaculation in rat may be directly mediated through dopaminergic pathways. Inhibition of ejaculation caused by these extracts could support its use in patients suffering from rapid ejaculation.
药用植物已成为发展中国家 70%以上人口的重要缓解来源，因为这些国家获得现代药物的途径非常有限。其中一些植物被用作壮阳药。在喀麦隆， Allanblackia floribunda Oliver（Clusiacea）的茎皮被用作壮阳药。
本研究旨在评估 Allanblackia floribunda 水提物和醇提物及其潜在机制对脊髓雄性大鼠虚构射精的影响。
在 24 组脊髓大鼠中，静脉给予 Allanblackia floribunda 茎皮的水提物和醇提物（2.5、10、20、40 或 60mg/kg）后，记录球海绵体肌的肌电图活动，存在或不存在多巴胺（60mg/kg）的情况下。此外，在存在多巴胺的情况下，对五组脊髓大鼠进行为期 8 天的口服预处理，记录提取物（150 和 300mg/kg）对球海绵体肌肌电图活动的影响。
连续用提取物处理大鼠可显著降低多巴胺诱导的射精发生，抑制率高达 88.94%。两种提取物的口服预处理均可显著降低多巴胺诱导的射精，最高抑制率为 89.79%。
本研究中使用的 Allanblackia floribunda 的两种提取物对射精具有抑制作用。Allanblackia floribunda 提取物对大鼠虚构射精的抑制作用可能是通过多巴胺能途径直接介导的。这些提取物引起的射精抑制作用可能支持其在快速射精患者中的应用。
