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A role for interleukin 4 in the differentiation of mature T cell receptor gamma/delta + cells from human intrathymic T cell precursors.白细胞介素4在人胸腺内T细胞前体向成熟T细胞受体γ/δ + 细胞分化中的作用。
J Exp Med. 1990 Aug 1;172(2):439-46. doi: 10.1084/jem.172.2.439.
2
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Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7689-93. doi: 10.1073/pnas.88.17.7689.
3
Activation of the interleukin 2 pathway precedes CD3-T cell receptor expression in thymic development. Differential growth requirements of early and mature intrathymic subpopulations.在胸腺发育过程中，白细胞介素2通路的激活先于CD3-T细胞受体的表达。胸腺内早期和成熟亚群的不同生长需求。
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In vitro expansion of CD3/TCR- human thymocyte populations that selectively lack CD3 delta gene expression: a phenotypic and functional analysis.选择性缺乏CD3δ基因表达的CD3/TCR-人类胸腺细胞群体的体外扩增：表型和功能分析。
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Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.外源性白细胞介素-7促进胎儿胸腺器官培养中CD3-CD4-CD8-CD44+CD25+/-前体细胞的生长，并阻断TCR-αβ细胞的分化途径。
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6
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Maturation or differentiation of human thymocyte precursors in vitro?人胸腺细胞前体在体外的成熟或分化？
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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.胸腺内携带T细胞抗原受体表型TCRαβ+和TCRγδ+的T细胞前体及其子代对人类免疫缺陷病毒感染易感性的证据：一种CD4+（T4）淋巴细胞耗竭的机制。
Proc Natl Acad Sci U S A. 1990 Oct;87(19):7727-31. doi: 10.1073/pnas.87.19.7727.
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Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation.通过胸腺内失活实现对转基因γδ T细胞的自身耐受。
Nature. 1990 Mar 8;344(6262):163-5. doi: 10.1038/344163a0.

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Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells.感染硕大利什曼原虫的BALB/c小鼠中γδ+ T细胞的扩增依赖于Th2型CD4+ T细胞。
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3
Involvement of the interleukin 4 pathway in the generation of functional gamma delta T cells from human pro-T cells.白细胞介素4信号通路在人原T细胞向功能性γδ T细胞分化过程中的作用
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7689-93. doi: 10.1073/pnas.88.17.7689.

本文引用的文献

1
Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies.与细胞溶解表达相关的人细胞毒性T细胞结构。I. 7种单克隆抗体细胞溶解抑制作用的克隆细胞水平分析。
Eur J Immunol. 1982 Sep;12(9):739-47. doi: 10.1002/eji.1830120908.
2
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
3
Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens.产生与外周血单个核细胞表面分化抗原发生反应的单克隆抗体。
J Immunol. 1980 Mar;124(3):1237-44.
4
Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.免疫化学证据表明，一个新的重排基因编码T细胞受体δ亚基。
Science. 1987 Oct 30;238(4827):682-4. doi: 10.1126/science.3672118.
5
Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).B细胞刺激因子1（白细胞介素4）对人外周血溶细胞性细胞群体的调节
J Exp Med. 1987 Nov 1;166(5):1447-55. doi: 10.1084/jem.166.5.1447.
6
Thymocyte clones from 14-day mouse embryos. I. State of T cell receptor genes, surface markers, and growth requirements.来自14日龄小鼠胚胎的胸腺细胞克隆。I. T细胞受体基因状态、表面标志物及生长需求。
J Exp Med. 1987 Nov 1;166(5):1245-58. doi: 10.1084/jem.166.5.1245.
7
Recombinant interleukin 4 promotes the growth of human T cells.重组白细胞介素4促进人T细胞的生长。
J Immunol. 1987 Aug 15;139(4):1142-7.
8
Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.白细胞介素4是活化胸腺细胞的生长因子：在T细胞个体发育中的可能作用。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3856-60. doi: 10.1073/pnas.84.11.3856.
9
Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones.白细胞介素-4介导人CD4 + T细胞克隆上CD8的诱导。
Nature. 1988 Oct 13;335(6191):642-4. doi: 10.1038/335642a0.
10
Analysis by in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice.通过原位杂交分析发育中小鼠胸腺和外周淋巴细胞中表达白细胞介素4信使核糖核酸的细胞。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):218-21. doi: 10.1073/pnas.85.1.218.

白细胞介素4在人胸腺内T细胞前体向成熟T细胞受体γ/δ + 细胞分化中的作用。

A role for interleukin 4 in the differentiation of mature T cell receptor gamma/delta + cells from human intrathymic T cell precursors.

作者信息

Bárcena A, Toribio M L, Pezzi L, Martínez C

机构信息

Centro de Biología Molecular, Universidad Autónoma de Madrid, Spain.

出版信息

J Exp Med. 1990 Aug 1;172(2):439-46. doi: 10.1084/jem.172.2.439.

DOI:10.1084/jem.172.2.439
PMID:2373988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188331/
Abstract

We have analyzed the effect of human recombinant interleukin 4 (rIL-4) on the growth and differentiation of human intrathymic pre-T cells (CD7+2+1-3-4-8-). We describe that this population of T cell precursors proliferates in response to rIL-4 (in the absence of mitogens or other stimulatory signals) in a dose-dependent way. The IL-4-induced proliferation is independent of the IL-2 pathway, as it cannot be inhibited with an anti-IL-2 receptor alpha chain antibody. In our culture conditions, rIL-4 also promotes the differentiation of pre-T cells into phenotypically mature T cells. Although both CD3/T cell receptor (TCR)-alpha/beta + and CD3-gamma/delta + T cells were obtained, the preferential differentiation into TCR-gamma/delta + cells was a consistent finding. These results suggest that, in addition to IL-2, IL-4 plays a critical role in promoting growth and differentiation of intrathymic T cell precursors at early stages of T cell development.

摘要

我们分析了重组人白细胞介素4（rIL-4）对人胸腺内前体T细胞（CD7+2+1-3-4-8-）生长和分化的影响。我们发现这群T细胞前体在无丝裂原或其他刺激信号的情况下，对rIL-4呈剂量依赖性增殖。IL-4诱导的增殖不依赖于IL-2途径，因为抗IL-2受体α链抗体不能抑制其增殖。在我们的培养条件下，rIL-4还能促进前体T细胞分化为表型成熟的T细胞。虽然同时获得了CD3/T细胞受体（TCR）-α/β+和CD3-γ/δ+T细胞，但优先分化为TCR-γ/δ+细胞是一个一致的发现。这些结果表明，除IL-2外，IL-4在T细胞发育早期促进胸腺内T细胞前体的生长和分化中起关键作用。