Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Aging Clin Exp Res. 2013 May;25(2):183-92. doi: 10.1007/s40520-013-0026-9. Epub 2013 Mar 29.
Alcohol is calorie dense, and impacts activity, appetite and lipid processing. The aim of this study was to therefore investigate the association between alcohol consumption and components of body composition including bone, fat and lean tissue.
Participants were recruited from a randomly selected, population-based sample of 534 men aged 65 years and older enrolled in the Geelong Osteoporosis Study. Alcohol intake was ascertained using a food frequency questionnaire and the sample categorised as non-drinkers or alcohol users who consumed ≤2, 3-4 or ≥5 standard drinks on a usual drinking day. Bone mineral density (BMD), lean body mass and body fat mass were measured using dual energy X-ray absorptiometry; overall adiposity (%body fat), central adiposity (%truncal fat) and body mass index (BMI) were calculated. Bone quality was determined by quantitative heel ultrasound (QUS).
There were 90 current non-drinkers (16.9 %), 266 (49.8 %) consumed 1-2 drinks/day, 104 (19.5 %) 3-4 drinks/day and 74 (13.8 %) ≥5 drinks/day. Those consuming ≥5 drinks/day had greater BMI (+4.8 %), fat mass index (+20.1 %), waist circumference (+5.0 %), %body fat (+15.2 %) and proportion of trunk fat (+5.3 %) and lower lean mass (-5.0 %) than non-drinkers after adjustment for demographic and lifestyle factors. Furthermore, they were more likely to be obese than non-drinkers according to criteria based on BMI (OR = 2.83, 95 %CI 1.10-7.29) or waist circumference (OR = 3.36, 95 %CI 1.32-8.54). There was an inverse relationship between alcohol consumption and QUS parameters and BMD at the mid forearm site; no differences were detected for BMD at other skeletal sites.
Higher alcohol intake was associated with greater total and central adiposity and reduced bone quality.
酒精热量密集，会影响活动、食欲和脂质代谢。因此，本研究旨在调查饮酒与身体成分各组成部分（包括骨、脂肪和瘦组织）之间的关联。
研究对象来自随机选择的、基于人群的、年龄在 65 岁及以上的 534 名男性参加的吉朗骨质疏松研究的样本。使用食物频率问卷确定饮酒量，将样本分为非饮酒者或饮酒者，饮酒者在通常饮酒日摄入≤2、3-4 或≥5 标准饮品。使用双能 X 射线吸收法测量骨矿物质密度 (BMD)、瘦体重和体脂肪量；计算总体肥胖度（%体脂肪）、中心肥胖度（%躯干脂肪）和体重指数 (BMI)。通过定量足跟超声 (QUS) 确定骨质量。
90 名当前非饮酒者（16.9%）、266 名（49.8%）每天饮用 1-2 份饮品、104 名（19.5%）每天饮用 3-4 份饮品和 74 名（13.8%）每天饮用≥5 份饮品。与非饮酒者相比，每天饮用≥5 份饮品者的 BMI（+4.8%）、脂肪质量指数（+20.1%）、腰围（+5.0%）、%体脂肪（+15.2%）和躯干脂肪比例（+5.3%）更高，瘦体重（-5.0%）更低，这些差异在调整人口统计学和生活方式因素后仍然存在。此外，根据 BMI（OR=2.83，95%CI 1.10-7.29）或腰围（OR=3.36，95%CI 1.32-8.54）标准，这些人肥胖的可能性也大于非饮酒者。饮酒与 QUS 参数和前臂中段 BMD 呈负相关，其他骨骼部位的 BMD 无差异。
较高的酒精摄入量与更大的总体和中心肥胖以及较低的骨质量有关。
