Gomes Wellington F, Lacerda Ana Cristina R, Mendonça Vanessa A, Arrieiro Arthur N, Fonseca Sueli F, Amorim Mateus R, Teixeira Antônio L, Teixeira Mauro M, Miranda Aline S, Coimbra Cândido C, Brito-Melo Gustavo E A
Integrated Center for Graduate Studies and Research Health (CIPq-Health), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil,
Rheumatol Int. 2014 Jun;34(6):841-6. doi: 10.1007/s00296-013-2786-0. Epub 2013 Jun 6.
Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the most affected by physical activity. Moreover, BDNF seems to have a negative modulatory role in inflammation, and its production by skeletal muscle cells or by cells of the immune system drives the immunoprotective role of physical activity in situations of chronic inflammation. Therefore, the aim of this study was to evaluate plasma BDNF concentrations in elderly individuals presenting with knee osteoarthritis. To accomplish this, sixteen volunteers (mean age 67 ± 4.41 years) presenting with clinically and radiographically diagnosed knee osteoarthritis were evaluated during acute exercise (1 session of 20 min on a treadmill) and after chronic exercise (12 weeks of aerobic training, consisting of a 50-min walk 3 times per week). Additionally, both a functional assessment (during a 6-min walk) and a pain perception assessment were performed at the start and at the end of physical exercises (training). The plasma BDNF concentrations were measured by ELISA. For the population studied, acute exercise increased the levels of BDNF only before the 12-week training period (p < 0.001). Moreover, the training augmented the plasma concentrations of BDNF (p < 0.0001) and improved clinical parameters (functional p < 0.001; pain perception p < 0.01).
膝关节骨关节炎是全球老年人群中的一种常见疾病。通过引发一系列分子和细胞过程的体育锻炼，可以缓解与该疾病相关的症状。在神经营养因子中，脑源性神经营养因子（BDNF）似乎受体育活动影响最大。此外，BDNF在炎症中似乎具有负调节作用，其由骨骼肌细胞或免疫系统细胞产生，在慢性炎症情况下发挥体育活动的免疫保护作用。因此，本研究的目的是评估患有膝关节骨关节炎的老年人血浆BDNF浓度。为实现这一目的，对16名临床和影像学诊断为膝关节骨关节炎的志愿者（平均年龄67±4.41岁）在急性运动期间（在跑步机上进行1次20分钟的运动）和慢性运动后（12周的有氧训练，包括每周3次50分钟的步行）进行了评估。此外，在体育锻炼（训练）开始和结束时进行了功能评估（6分钟步行期间）和疼痛感知评估。通过酶联免疫吸附测定法（ELISA）测量血浆BDNF浓度。对于所研究的人群，急性运动仅在12周训练期之前增加了BDNF水平（p<0.001）。此外，训练提高了血浆BDNF浓度（p<0.0001）并改善了临床参数（功能p<0.001；疼痛感知p<0.01）。
