水溶性 Au(III)/TPPMS 体系水相中对未保护的邻氨基苯甲酸的苄基化反应的选择性研究。
Chemoselective benzylation of unprotected anthranilic acids with benzhydryl alcohols by water-soluble Au(III)/TPPMS in water.
机构信息
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
出版信息
J Org Chem. 2013 Jul 5;78(13):6714-20. doi: 10.1021/jo401064f. Epub 2013 Jun 18.
PMID:23745757
Abstract
A novel and efficient method for the benzylation of unprotected anthranilic acids with benzhydryl alcohols using water-soluble Au(III)/TPPMS in water is developed. Water plays an important role in our catalytic system. This new protocol could be used for not only N-benzylation, but also chemoselective C-benzylation by the Friedel-Crafts reaction.
摘要
开发了一种在水中使用水溶性 Au(III)/TPPMS 高效、新颖的苄基化未保护的邻氨基苯甲酸与苄醇的方法。水在我们的催化体系中起着重要作用。这个新的方案不仅可用于 N-苄基化，还可通过傅克反应选择性地进行 C-苄基化。
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