三价金/三苯基膦甲烷磺酸钠催化吲哚与苄醇在水中的苄基化反应。
Au(III)/TPPMS-catalyzed benzylation of indoles with benzylic alcohols in water.
机构信息
Faculty of Pharmaceutical Sciences, Toho University , 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan.
出版信息
J Org Chem. 2013 Dec 6;78(23):12128-35. doi: 10.1021/jo402151g. Epub 2013 Nov 22.
PMID:24256426
Abstract
A novel and efficient method for the Au(III)/TPPMS-catalyzed direct substitution reaction of benzhydryl and benzylic alcohols with indoles in water is developed. Au(III)/TPPMS is an effective catalyst for the benzylation of the strong π nucleophile 1-methylindole, while common Brønsted or Lewis acids are ineffective.
摘要
发展了一种新颖高效的 Au(III)/TPPMS 催化水中苯甲醇和苄醇与吲哚的直接取代反应的方法。Au(III)/TPPMS 是强碱亲核试剂 1-甲基吲哚的有效苄基化试剂，而常见的布朗斯特酸或路易斯酸则无效。
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