Public Dental Health Service, Master in Oral Surgery and Medicine, Master in Oral Surgery and Medicine, Master in Oral Surgery and Implantology, Valencia University Medical and Dental School, Valencia, Spain.
Int J Oral Maxillofac Implants. 2013 May-Jun;28(3):883-90. doi: 10.11607/jomi.2654.
To analyze the clinical, microbiologic, and host response characteristics (interleukins 1β and 6) in the peri-implant sulcus fluid (PISF) of patients with healthy dental implants and with peri-implant mucositis.
Clinical parameters (modified Gingival Index [mGI], modified Plaque Index [mPI], probing pocket depth [PPD], and absence or presence of radiologic bone loss) were recorded, and PISF samples were obtained from peri-implant sites showing mucositis as well as healthy sites. The periodontopathogenic bacteria Tannerella forsythia (Tf), Treponema denticola (Td), and Porphyromonas gingivalis (Pg) were evaluated, together with the total bacterial load (TBL) and the interleukin (IL) 1β and IL-6 values.
The study population consisted of 34 individuals, and 77 dental implants were evaluated during the study (23 mucositis and 54 healthy peri-implant sites). The mGI, mPI, and PPD scores of the peri-implant mucositis group were significantly greater than in the healthy group. No differences in detection frequency were found for putative periodontal pathogens and TBL between the healthy peri-implant sites and mucositis sites. The mucositis group showed a significantly greater expression of IL-6 than the healthy group (P < .05). Although IL-1β was increased in the mucositis group, there was no statistically significant difference versus the healthy implant group.
An analysis was made of the clinical, microbiologic, and host response characteristics in implants with peri-implant mucositis, establishing comparisons with healthy implants. In the patients studied, bacterial plaque induced an inflammatory response that can lead to the development of peri-implant mucositis. Adequate plaque control is therefore able to increase peri-implant health, avoiding the risk of future complications. No specific association to the studied bacterial species was established.
分析患有健康牙种植体和种植体周围黏膜炎的患者的种植体周围龈沟液（PISF）的临床、微生物学和宿主反应特征（白细胞介素 1β 和 6）。
记录临床参数（改良龈指数[mGI]、改良菌斑指数[mPI]、探诊袋深度[PPD]以及有无放射状骨丧失），并从表现为黏膜炎的种植体部位以及健康部位获取 PISF 样本。评估牙周病原体 Tannerella forsythia（Tf）、Treponema denticola（Td）和 Porphyromonas gingivalis（Pg），以及总细菌负荷（TBL）和白细胞介素（IL）1β和 IL-6 值。
该研究人群由 34 名个体组成，在研究期间评估了 77 个牙种植体（23 个黏膜炎和 54 个健康种植体部位）。种植体周围黏膜炎组的 mGI、mPI 和 PPD 评分明显大于健康组。在健康种植体部位和黏膜炎部位之间，未发现潜在牙周病原体和 TBL 的检测频率有差异。黏膜炎组的 IL-6 表达明显高于健康组（P<.05）。尽管黏膜炎组的 IL-1β 增加，但与健康种植体组相比，差异无统计学意义。
对患有种植体周围黏膜炎的种植体进行了临床、微生物学和宿主反应特征分析，并与健康种植体进行了比较。在研究的患者中，细菌菌斑引起了炎症反应，可能导致种植体周围黏膜炎的发生。因此，适当的菌斑控制能够增加种植体周围的健康，避免未来并发症的风险。未确定与研究细菌种类的具体关联。
