Architecture et Fonction des Macromolécules Biologiques, Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7257, Case 932, 163 Avenue de Luminy, 13288 Marseille cedex 9, France.
Nat Rev Microbiol. 2013 Jul;11(7):497-504. doi: 10.1038/nrmicro3050. Epub 2013 Jun 10.
Descriptions of the microbial communities that live on and in the human body have progressed at a spectacular rate over the past 5 years, fuelled primarily by highly parallel DNA-sequencing technologies and associated advances in bioinformatics, and by the expectation that understanding how to manipulate the structure and functions of our microbiota will allow us to affect health and prevent or treat diseases. Among the myriad of genes that have been identified in the human gut microbiome, those that encode carbohydrate-active enzymes (CAZymes) are of particular interest, as these enzymes are required to digest most of our complex repertoire of dietary polysaccharides. In this Analysis article, we examine the carbohydrate-digestive capacity of a simplified but representative mini-microbiome in order to highlight the abundance and variety of bacterial CAZymes that are represented in the human gut microbiota.
在过去的 5 年中，描述栖息在人体上和人体内部的微生物群落的工作取得了惊人的进展，这主要得益于高度并行的 DNA 测序技术和相关的生物信息学进展，以及人们期望了解如何操纵我们的微生物群落的结构和功能，从而能够影响健康并预防或治疗疾病。在人类肠道微生物组中已经鉴定出的无数基因中，那些编码碳水化合物活性酶（CAZymes）的基因特别引人关注，因为这些酶是消化我们复杂的膳食多糖的必需物质。在这篇分析文章中，我们检查了一个简化但具有代表性的迷你微生物组的碳水化合物消化能力，以突出代表人类肠道微生物组的细菌 CAZymes 的丰富度和多样性。
