The Institute of Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA.
Nat Rev Microbiol. 2013 Jul;11(7):467-81. doi: 10.1038/nrmicro3047. Epub 2013 Jun 10.
Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with elaborate chemical moieties, which effectively disguises them from immune surveillance and protects them from the onslaught of host defences. Many of these changes occur on the lipid A moiety of lipopolysaccharide, a component that is crucial for host recognition of Gram-negative infection. In this Review, we describe the regulatory mechanisms controlling lipid A modification and discuss the impact of modifications on pathogenesis, bacterial physiology and bacterial interactions with the host immune system.
革兰氏阴性菌用精细的化学基团来装饰它们最外层的表面结构——脂多糖，这有效地使它们逃避免疫监视，并保护它们免受宿主防御系统的攻击。这些变化中的许多发生在脂多糖的脂质 A 部分，该成分对于宿主识别革兰氏阴性感染至关重要。在这篇综述中，我们描述了控制脂质 A 修饰的调节机制，并讨论了修饰对发病机制、细菌生理学以及细菌与宿主免疫系统相互作用的影响。
