Hudry Kristelle, Chandler Susie, Bedford Rachael, Pasco Greg, Gliga Teodora, Elsabbagh Mayada, Johnson Mark H, Charman Tony
Olga Tennison Autism Research Centre, School of Psychological Science, La Trobe University, Melbourne, VIC, 3086, Australia,
J Autism Dev Disord. 2014 Jan;44(1):154-67. doi: 10.1007/s10803-013-1861-4.
Many preschoolers with autism spectrum disorders (ASD) present relative lack of receptive advantage over concurrent expressive language. Such profile emergence was investigated longitudinally in 54 infants at high-risk (HR) for ASD and 50 low-risk controls, with three language measures taken across four visits (around 7, 14, 24, 38 months). HR infants presented three outcome subgroups: ASD, other atypicality, and typical development. Reduced receptive vocabulary advantage was observed in HR infants by 14 months, but was maintained to 24 months only in ASD/other atypicality outcome subgroups while typically-developing HR infants regained a more normative profile. Few group differences appeared on a direct assessment of language and parent-reported functional communication. Processes of early development toward ASD outcome and in intermediate phenotypes are discussed.
许多患有自闭症谱系障碍（ASD）的学龄前儿童在接受性语言方面相对缺乏优于同时期表达性语言的优势。在54名ASD高危（HR）婴儿和50名低危对照组婴儿中对这种情况的出现进行了纵向研究，在四次访视（约7、14、24、38个月）中采用了三种语言测量方法。HR婴儿呈现出三个结果亚组：ASD、其他非典型性和典型发育。HR婴儿在14个月时接受性词汇优势降低，但仅在ASD/其他非典型性结果亚组中维持到24个月，而发育正常的HR婴儿恢复了更正常的情况。在直接语言评估和家长报告的功能性沟通方面几乎没有组间差异。本文讨论了向ASD结果和中间表型早期发展的过程。
