Lipperheide V, Quindós G, Jiménez Y, Pontón J, Bagán-Sebastián J V, Aguirre J M
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco (UPV-EHU), Bilbao, Spain.
Mycopathologia. 1996;134(2):75-82. doi: 10.1007/BF00436868.
Prevalence of yeasts in 35 leukoplakia and 34 oral lichen planus patients was compared with that observed in persons without oral diseases. Serotype and morphotype were determined on Candida albicans isolates. Yeasts were isolated from the oral cavity specimens of 43.7% of the patients. C. albicans (serotype A) was the predominant species (76% in leukoplakia, 88.2% in lichen planus and 60.8% in healthy persons). Sixteen morphotypes were encountered on malt extract agar, being 732, 733, 734, 753 and 754 the most frequently found. Morphotypes SP1N and SP1Y were the most common on Sabouraud-trypheniltetrazolium agar (68.4% of the isolates from leukoplakia and 73.3% from lichen planus, but only 46.6% of the isolates from healthy oral mucosa showed SP1N morphotype). Presence of oral lesions was associated with a marked reduction in the yeast species and C. albicans biotypes, suggesting that C. albicans and particularly some of its biotypes, show a high potential of adaptation to the changes associated with the development of oral leukoplakia and lichen planus.
比较了35例白斑患者和34例口腔扁平苔藓患者中酵母菌的患病率与无口腔疾病者的患病率。对白色念珠菌分离株进行了血清型和形态型鉴定。从43.7%的患者口腔标本中分离出酵母菌。白色念珠菌（血清型A）是主要菌种（白斑患者中占76%，扁平苔藓患者中占88.2%，健康人中占60.8%）。在麦芽提取物琼脂上发现了16种形态型，其中732、733、734、753和754最为常见。在沙氏-三苯四氮唑琼脂上，形态型SP1N和SP1Y最为常见（白斑患者分离株中占68.4%，扁平苔藓患者分离株中占73.3%，但健康口腔黏膜分离株中只有46.6%显示SP1N形态型）。口腔病变的存在与酵母菌种类和白色念珠菌生物型的显著减少有关，这表明白色念珠菌尤其是其某些生物型，对与口腔白斑和扁平苔藓发展相关的变化具有很高的适应潜力。
