Lewine R R, Gulley L R, Risch S C, Jewart R, Houpt J L
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322.
Schizophr Bull. 1990;16(2):195-203. doi: 10.1093/schbul/16.2.195.
The study of sexual dimorphism in brain morphology may help delineate subtypes of schizophrenia based, in part, on sex; yield insight into the relationship between brain structure and behavior; and provide a neurodevelopmental context for studying the ontogenesis of schizophrenia. Preliminary findings from an ongoing study of sex differences in brain morphology and neuropsychological performance in schizophrenia suggest that schizophrenic males are characterized by multiple morphological deviations; this may represent an extreme form of normal sexual dimorphism in brain morphology. The role of brain morphology deviation in the ontogenesis of schizophrenia is discussed.
对大脑形态学中性别差异的研究可能有助于部分基于性别来划分精神分裂症的亚型；深入了解大脑结构与行为之间的关系；并为研究精神分裂症的个体发生提供神经发育背景。一项正在进行的关于精神分裂症患者大脑形态和神经心理表现的性别差异研究的初步结果表明，精神分裂症男性患者具有多种形态学偏差；这可能代表了大脑形态学中正常性别差异的一种极端形式。本文讨论了大脑形态学偏差在精神分裂症个体发生中的作用。
