淋巴细胞对动脉抗原的增殖反应作为风湿性多肌痛的阳性诊断试验。
Lymphocyte proliferation to artery antigen as a positive diagnostic test in polymyalgia rheumatica.
作者信息
Hazleman B L, Maclennan I C, Esiri M M
出版信息
Ann Rheum Dis. 1975 Apr;34(2):122-7. doi: 10.1136/ard.34.2.122.
Abstract
The transformation response of peripheral blood lymphocytes in vitro to human arterial and muscle antigen has been studied in patients with polymyalgia rheumatica, polymyositis, rheumatoid arthritis, and polyarteritis, and polyarteritis nodosa and in unrelated controls. Lymphocytes from patients with polymyalgia rheumatica showed transformation responses significantly higher to artery antigen than those in the other disease and control groups. The highest responses were found in patients with evidence of the most active clinical disease at the time of testing. It is suggested that the transformation response to arterial antigen might aid the diagnosis of polymyalgia rheumatica.
摘要
对风湿性多肌痛、多发性肌炎、类风湿性关节炎、结节性多动脉炎患者以及健康对照者，研究了其外周血淋巴细胞在体外对人动脉和肌肉抗原的转化反应。风湿性多肌痛患者的淋巴细胞对动脉抗原的转化反应显著高于其他疾病组和对照组。检测时临床疾病最活跃的患者反应最高。提示对动脉抗原的转化反应可能有助于风湿性多肌痛的诊断。
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