Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Mar Drugs. 2013 May 29;11(6):1853-65. doi: 10.3390/md11061853.
Five new pregnane-type steroids, sclerosteroids J-N (1-5), and a diterpenoid with a new chemotype 3-methyl-5-(10'-acetoxy-2',6',10'-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
从软珊瑚 Scleronephthya gracillimum 中分离得到五个新的孕甾烷型甾体化合物 sclerosteroids J-N（1-5）和一个具有新型化学型的二萜 3-甲基-5-(10'-乙酰氧基-2',6',10'-三甲基十一烷基)-2-戊烯-5-内酯（6）。通过广泛的光谱分析确定了代谢产物的结构。化合物 4 对 HepG2、A549 和 MDA-MB-231 癌细胞系表现出细胞毒性。此外，甾体 2 和 4 被发现可显著抑制促炎 iNOS 蛋白的积累，并且 1、2、4 和 5 可有效减少 LPS 刺激的 RAW264.7 巨噬细胞中 COX-2 蛋白的积累。
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