Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA 02115, USA.
Cancer Prev Res (Phila). 2013 Aug;6(8):811-21. doi: 10.1158/1940-6207.CAPR-13-0037. Epub 2013 Jun 12.
Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with number of genital powder applications and for all histologic types of ovarian cancer also remains uncertain. Therefore, we estimated the association between self-reported genital powder use and epithelial ovarian cancer risk in eight population-based case-control studies. Individual data from each study were collected and harmonized. Lifetime number of genital powder applications was estimated from duration and frequency of use. Pooled ORs were calculated using conditional logistic regression matched on study and age and adjusted for potential confounders. Subtype-specific risks were estimated according to tumor behavior and histology. 8,525 cases and 9,859 controls were included in the analyses. Genital powder use was associated with a modest increased risk of epithelial ovarian cancer [OR, 1.24; 95% confidence interval (CI), 1.15-1.33] relative to women who never used powder. Risk was elevated for invasive serous (OR, 1.20; 95% CI, 1.09-1.32), endometrioid (OR, 1.22; 95% CI, 1.04-1.43), and clear cell (OR, 1.24; 95% CI, 1.01-1.52) tumors, and for borderline serous tumors (OR, 1.46; 95% CI, 1.24-1.72). Among genital powder users, we observed no significant trend (P = 0.17) in risk with increasing number of lifetime applications (assessed in quartiles). We noted no increase in risk among women who only reported nongenital powder use. In summary, genital powder use is a modifiable exposure associated with small-to-moderate increases in risk of most histologic subtypes of epithelial ovarian cancer.
使用阴部爽身粉与某些但不是所有的流行病学研究中的上皮性卵巢癌风险相关，这可能反映了大多数这些产品中滑石颗粒的致癌作用。使用阴部爽身粉的次数是否会增加风险以及是否会增加所有组织学类型的卵巢癌风险也尚不确定。因此，我们估计了在 8 项基于人群的病例对照研究中，自我报告的阴部爽身粉使用与上皮性卵巢癌风险之间的关联。从使用持续时间和频率来估计终生使用阴部爽身粉的次数。使用条件逻辑回归进行汇总，匹配研究和年龄，并调整潜在混杂因素。根据肿瘤行为和组织学估计特定亚型的风险。纳入了 8525 例病例和 9859 例对照进行分析。与从未使用过爽身粉的女性相比，使用阴部爽身粉与上皮性卵巢癌风险略有增加（OR，1.24；95%置信区间[CI]，1.15-1.33）。侵袭性浆液性（OR，1.20；95%CI，1.09-1.32）、子宫内膜样（OR，1.22；95%CI，1.04-1.43）和透明细胞（OR，1.24；95%CI，1.01-1.52）肿瘤以及交界性浆液性肿瘤（OR，1.46；95%CI，1.24-1.72）的风险升高。在阴部爽身粉使用者中，我们观察到随着终生使用次数的增加（按四分位数评估），风险无显著趋势（P=0.17）。我们没有发现仅报告非阴部爽身粉使用的女性风险增加。总之，使用阴部爽身粉是一种可改变的暴露因素，与大多数上皮性卵巢癌组织学亚型的小到中度风险增加相关。
