Cook L S, Kamb M L, Weiss N S
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Am J Epidemiol. 1997 Mar 1;145(5):459-65. doi: 10.1093/oxfordjournals.aje.a009128.
This case-control study evaluated the risk of epithelial ovarian cancer associated with genital exposure to various forms of powder application. Cases included all women aged 20-79 years in three counties of western Washington who were diagnosed with borderline or invasive ovarian cancer from 1986 through 1988; 64.3% of eligible cases were interviewed. A sample of similarly aged women who lived in these counties, identified by random digit dialing, served as controls. The overall response among control women was 68.0%. Information on powder application and other potential risk factors was ascertained during the in-person interview. Overall, ovarian cancer cases (n = 313) were more likely than controls (n = 422) to ever have used powder (age-adjusted relative risk (RR) = 1.5, 95% confidence interval (CI) 1.1-2.0). After adjustment for age and other methods of genital powder application (none vs. any), an elevated relative risk of ovarian cancer was noted only for women with a history of perineal dusting (RR = 1.6, 95% CI 1.1-2.3) or use of genital deodorant spray (RR = 1.9, 95% CI 1.1-3.1). These results offer support for the hypothesis, raised by prior epidemiologic studies, that powder exposure from perineal dusting contributes to the development of ovarian cancer, and they suggest that use of genital deodorant sprays may do so as well. Limitations of the present study include the fairly low proportion of eligible women who participated and the potential differential recall of powder usage.
这项病例对照研究评估了因生殖器接触各种形式的粉剂涂抹而患上皮性卵巢癌的风险。病例包括1986年至1988年期间在华盛顿州西部三个县被诊断为交界性或浸润性卵巢癌的所有20至79岁女性；64.3%符合条件的病例接受了访谈。通过随机数字拨号确定的居住在这些县的年龄相仿的女性样本作为对照。对照女性的总体回应率为68.0%。在面对面访谈中确定了关于粉剂涂抹及其他潜在风险因素的信息。总体而言，卵巢癌病例（n = 313）比对照（n = 422）更有可能使用过粉剂（年龄调整相对风险（RR）= 1.5，95%置信区间（CI）1.1 - 2.0）。在对年龄和其他生殖器粉剂涂抹方法（无涂抹与有涂抹）进行调整后，仅发现有会阴撒粉史（RR = 1.6，95% CI 1.1 - 2.3）或使用生殖器除臭喷雾（RR = 1.9，95% CI 1.1 - 3.1）的女性患卵巢癌的相对风险升高。这些结果支持了先前流行病学研究所提出的假说，即会阴撒粉导致的粉剂接触会促使卵巢癌的发生，并且表明使用生殖器除臭喷雾也可能有此作用。本研究的局限性包括参与的符合条件女性比例相当低以及粉剂使用情况可能存在的回忆差异。
