Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J Nutr. 2013 Aug;143(8):1340-7. doi: 10.3945/jn.113.174383. Epub 2013 Jun 12.
Recent studies have indicated that omega-3 (n3) polyunsaturated fatty acids (PUFAs) decrease adipose tissue inflammation in rodents and in morbidly obese humans. We investigated whether a diet rich in n3 PUFAs from both marine and plant sources reduces adipose tissue and systemic inflammation in overweight to moderately obese adults. We conducted a randomized, single-blind, parallel-design, placebo-controlled feeding trial. Healthy men and women with a body mass index between 28 and 33 kg/m(2) consumed a diet rich in n3 PUFAs (3.5% of energy intake; n = 11) from plant and marine sources or a control diet (0.5% of energy intake from n3 PUFAs; n = 13). These diets were consumed for 14 wk (ad libitum for 12 wk). All foods were provided for the entire study period. Subcutaneous abdominal adipose tissue and fasting plasma were collected after the first 2 wk with the control diet and again at the end of the 14-wk dietary period. The primary outcome of this ex post analysis was the adipose tissue gene expression of 13 key mediators of inflammation. Adipose tissue gene expression of inflammatory mediators did not differ between the 2 groups, after adjustment for weight change. Furthermore, none of the 5 plasma markers of systemic inflammation differed significantly as an effect of diet treatment. We conclude that a relatively high dose of n3 PUFAs from plant and marine sources did not significantly lower adipose tissue or systemic inflammation in overweight to moderately obese healthy men and women over 14 wk.
最近的研究表明，ω-3（n3）多不饱和脂肪酸（PUFAs）可减少啮齿动物和病态肥胖人群的脂肪组织炎症。我们研究了富含来自海洋和植物来源的 n3 PUFAs 的饮食是否会降低超重至中度肥胖成年人的脂肪组织和全身炎症。我们进行了一项随机、单盲、平行设计、安慰剂对照喂养试验。身体质量指数（BMI）在 28 至 33kg/m²之间的健康男性和女性摄入富含来自植物和海洋来源的 n3 PUFAs（占能量摄入的 3.5%；n = 11）或对照饮食（n3 PUFAs 占能量摄入的 0.5%；n = 13）。这些饮食以随意的方式（12 周）摄入 14 周。在整个研究期间，都为参与者提供所有食物。在控制饮食的最初 2 周后和 14 周饮食期结束时，采集皮下腹部脂肪组织和空腹血浆。本事后分析的主要结果是 13 种关键炎症介质的脂肪组织基因表达。调整体重变化后，两组间炎症介质的脂肪组织基因表达无差异。此外，作为饮食治疗效果，5 种血浆系统炎症标志物均无显著差异。我们的结论是，富含来自植物和海洋来源的相对较高剂量的 n3 PUFAs 在 14 周内不会显著降低超重至中度肥胖的健康男性和女性的脂肪组织或全身炎症。
