三氟甲基化反应在β-三氟甲基胺合成中的应用。
Trifluoromethylation reactions for the synthesis of β-trifluoromethylamines.
机构信息
Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
出版信息
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7841-4. doi: 10.1002/anie.201303350. Epub 2013 Jun 13.
PMID:23765709
Abstract
A multitalented system: N-migratory oxytrifluoromethylation and one-pot three-component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent (1) and CuI to afford a variety of β-trifluoromethylamine derivatives (see scheme).
摘要
一个多用途的体系
在 Togni 试剂（1）和 CuI 的存在下，烯丙胺的 N-迁移性氧三氟甲基化和一锅法三组分反应以及烯基胺的氨三氟甲基化都能高效进行，从而得到各种β-三氟甲基胺衍生物（见方案）。
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