Department of Microbiology and Research Center for Medical Sciences, Chung-Ang University College of Medicine, Seoul, South Korea.
J Med Virol. 2013 Aug;85(8):1478-84. doi: 10.1002/jmv.23587.
During an epidemiological survey of human rotavirus infection in Seoul, Korea, from 2010 to 2011, one isolate of group C rotavirus (GCRV), named CAU10-312, was detected in a 5-year-old child admitted to the hospital with acute gastroenteritis, and its complete genomic sequence was determined. The 11 gene segments of the strain possessed G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2 genotypes. The genotype of strain CAU10-312 appears to be closely related to strains from Bangladesh (DhakaC13 and BS347), India (v508), and England (Bristol), but distinct from Far East Asian strains, Chinese (Wu82 and YNR001) and Japanese (OH567 and BK0830). These findings may clarify the relationship of the genetics, evolutionary biology, and epidemiology of GCRVs and suggest that two very distinct genotype strains are in circulation in the world.
在 2010 年至 2011 年期间对韩国首尔地区的人类轮状病毒感染进行的流行病学调查中，从一名因急性肠胃炎住院的 5 岁儿童中检测到一株 C 组轮状病毒（GCRV），命名为 CAU10-312，并确定了其完整的基因组序列。该毒株的 11 个基因片段具有 G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2 基因型。株 CAU10-312 的基因型似乎与孟加拉国（达卡 C13 和 BS347）、印度（v508）和英国（布里斯托尔）的菌株密切相关，但与东亚地区的中国（Wu82 和 YNR001）和日本（OH567 和 BK0830）的菌株不同。这些发现可能阐明了 GCRV 的遗传学、进化生物学和流行病学之间的关系，并表明在世界范围内存在两种非常不同的基因型流行株。
