Department of Microbiology, Chung-Ang University College of Medicine, 06974, Seoul, South Korea.
Central Vietnam Veterinary Institute, Nha Trang, Vietnam.
Arch Virol. 2022 Nov;167(11):2163-2171. doi: 10.1007/s00705-022-05528-1. Epub 2022 Jul 16.
Globally, rotavirus C (RVC) causes diarrhoeal outbreaks, mainly in swine, with sporadic incidents in human, bovine, and canine populations. In this study, two human RVC strains, RVC/Human-wt/KOR/CAU13-1-77/2013 and RVC/Human-wt/KOR/CAU14-1-242/2014, were isolated in South Korea, and their complete genome sequences were compared with those of other human- and animal-origin RVC strains found worldwide. Genetic analysis revealed that these viruses have a G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype constellation. Phylogenetic analysis indicated that these Korean RVC strains belong to the M3 lineage of the VP3 gene in human RVC from Japan and China and porcine RVC from Japan. These results suggest that RVC circulates in northeast Asia in both the human and porcine populations. These results also provide evidence of interspecies RVC reassortment events.
全球范围内，轮状病毒 C（RVC）主要引起猪的腹泻性爆发，偶尔也会在人类、牛和犬类中发生。在这项研究中，两种人类 RVC 株，RVC/Human-wt/KOR/CAU13-1-77/2013 和 RVC/Human-wt/KOR/CAU14-1-242/2014，在韩国被分离出来，并且它们的完整基因组序列与在全球范围内发现的其他源自人类和动物的 RVC 株进行了比较。遗传分析显示，这些病毒具有 G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 基因型组合。系统进化分析表明，这些韩国 RVC 株属于来自日本和中国的人类 RVC 以及来自日本的猪 RVC 的 VP3 基因的 M3 谱系。这些结果表明 RVC 在东亚的人类和猪群中传播。这些结果还提供了种间 RVC 重组事件的证据。
