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1
Propranolol in use for treatment of complex infant hemangiomas: literature review regarding current guidelines for preassessment and standards of care before initiation of therapy.普萘洛尔用于治疗复杂型婴儿血管瘤：关于治疗开始前预评估现行指南及护理标准的文献综述
ScientificWorldJournal. 2013 May 20;2013:850193. doi: 10.1155/2013/850193. Print 2013.
2
[Infantile hemangioma and propranolol: a therapeutic "revolution". Literature review].[婴儿血管瘤与普萘洛尔：一场治疗“革命”。文献综述]
Rev Med Brux. 2013 Nov-Dec;34(6):479-84.
3
Utility of routine electrocardiographic screening before initiation of propranolol for infantile hemangiomas.普萘洛尔用于婴儿血管瘤治疗前常规心电图筛查的效用
Pediatr Dermatol. 2018 Jul;35(4):e233-e234. doi: 10.1111/pde.13508. Epub 2018 Apr 23.
4
Serum and tissue profile of VEGF and its receptors VGFR1/R2 in children with infantile hemangiomas on systemic propranolol treatment.接受全身性普萘洛尔治疗的婴幼儿血管瘤患儿血清及组织中VEGF及其受体VGFR1/R2的概况
Immunol Lett. 2016 Jul;175:44-9. doi: 10.1016/j.imlet.2016.05.002. Epub 2016 May 10.
5
Serum cytokine profiles in infants with infantile hemangiomas on oral propranolol treatment: VEGF and bFGF, potential biomarkers predicting clinical outcomes.口服普萘洛尔治疗婴儿血管瘤婴儿的血清细胞因子谱：VEGF 和 bFGF，预测临床结局的潜在生物标志物。
Pediatr Res. 2020 Nov;88(5):749-755. doi: 10.1038/s41390-020-0862-1. Epub 2020 Apr 20.
6
Propranolol induced hypoglycemia.普萘洛尔诱发低血糖症。
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7
Beta Blockade as Treatment for Intracranial Infantile Hemangioma: Case Report and Literature Review.β受体阻滞剂治疗颅内婴儿血管瘤：病例报告及文献综述
Pediatr Neurol. 2016 Jun;59:13-7. doi: 10.1016/j.pediatrneurol.2016.01.018. Epub 2016 Feb 1.
8
Oral propranolol: an effective, safe treatment for infantile hemangiomas.口服普萘洛尔：治疗婴儿血管瘤的有效、安全方法。
Eur J Dermatol. 2011 Jul-Aug;21(4):558-63. doi: 10.1684/ejd.2011.1372.
9
Propranolol for infantile hemangioma (PINCH): an open-label trial to assess the efficacy of propranolol for treating infantile hemangiomas and for determining the decline in heart rate to predict response to propranolol.普萘洛尔治疗婴幼儿血管瘤（PINCH）：一项开放标签试验，以评估普萘洛尔治疗婴幼儿血管瘤的疗效，并确定心率下降情况以预测对普萘洛尔的反应。
J Pediatr Hematol Oncol. 2013 Oct;35(7):493-9. doi: 10.1097/MPH.0b013e3182a11658.
10
Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.普萘洛尔时代治疗婴幼儿血管瘤手术的临床和经济影响：马德里拉帕兹医院单中心经验概述。
Eur J Pediatr. 2019 Jan;178(1):1-6. doi: 10.1007/s00431-018-3290-z. Epub 2018 Nov 12.

引用本文的文献

1
Propranolol for Vascular Anomalies: Efficacy and Complications in Pediatric Patients.普萘洛尔治疗血管异常：儿科患者的疗效与并发症
J Indian Assoc Pediatr Surg. 2023 May-Jun;28(3):194-205. doi: 10.4103/jiaps.jiaps_117_22. Epub 2023 May 2.
2
Propranolol-induced hyperkalemia in infantile hemangioma patients: How serious is it?普萘洛尔诱发婴儿血管瘤患者高钾血症：严重程度如何？
J Family Med Prim Care. 2022 Nov;11(11):6944-6948. doi: 10.4103/jfmpc.jfmpc_658_22. Epub 2022 Dec 16.
3
Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate.成人头颈部血管瘤的治疗：口服普萘洛尔与口服伊曲康唑联合十四烷基硫酸钠注射的对比
Indian J Otolaryngol Head Neck Surg. 2019 Oct;71(Suppl 1):566-573. doi: 10.1007/s12070-018-1410-8. Epub 2018 Jun 4.
4
Deep coma in a child treated with propranolol for infantile hemangioma.儿童接受普萘洛尔治疗婴儿血管瘤后陷入深度昏迷。
BMC Pediatr. 2019 Jul 2;19(1):216. doi: 10.1186/s12887-019-1598-0.
5
Propranolol pharmacokinetics in infants treated for Infantile Hemangiomas requiring systemic therapy: Modeling and dosing regimen recommendations.普萘洛尔在婴儿血管瘤系统治疗中婴儿的药代动力学：模型建立和给药方案建议。
Pharmacol Res Perspect. 2018 Apr 30;6(3):e00399. doi: 10.1002/prp2.399. eCollection 2018 Jun.
6
Mesenteric infantile hemangioma: diagnostic work-up.肠系膜婴儿血管瘤：诊断检查
Quant Imaging Med Surg. 2018 Mar;8(2):252-256. doi: 10.21037/qims.2017.09.01.
7
Successful management of extremely high-output refractory congenital chylothorax with chemical pleurodesis using 4% povidone-iodine and propranolol: a case report.使用4%聚维酮碘和普萘洛尔进行化学性胸膜固定术成功治疗极高输出量难治性先天性乳糜胸：一例报告
Clin Case Rep. 2018 Feb 27;6(4):702-708. doi: 10.1002/ccr3.1449. eCollection 2018 Apr.
8
Effect of 22 Novel Cytochrome P450 2D6 (CYP2D6) Variants Found in the Chinese Population on Hemangeol Metabolism In Vitro.在中国人群中发现的22种新型细胞色素P450 2D6（CYP2D6）变体对血管瘤代谢的体外影响。
Eur J Drug Metab Pharmacokinet. 2016 Dec;41(6):759-765. doi: 10.1007/s13318-015-0307-0.

本文引用的文献

1
Initiation and use of propranolol for infantile hemangioma: report of a consensus conference.普萘洛尔治疗婴幼儿血管瘤：共识会议报告。
Pediatrics. 2013 Jan;131(1):128-40. doi: 10.1542/peds.2012-1691. Epub 2012 Dec 24.
2
Infantile hemangiomas: an update on pathogenesis and therapy.婴幼儿血管瘤：发病机制和治疗的最新进展。
Pediatrics. 2013 Jan;131(1):99-108. doi: 10.1542/peds.2012-1128. Epub 2012 Dec 24.
3
Propranolol is an effective treatment for airway haemangiomas: a critical analysis and meta-analysis of published interventional studies.普萘洛尔是治疗气道血管瘤的有效方法：对已发表的介入性研究的批判性分析和荟萃分析。
Acta Otorhinolaryngol Ital. 2012 Aug;32(4):213-21.
4
Propranolol treatment for severe infantile hemangiomas: a single-centre 3-year experience.普萘洛尔治疗严重婴儿血管瘤：单中心 3 年经验。
Acta Paediatr. 2012 Oct;101(10):e469-74. doi: 10.1111/j.1651-2227.2012.02783.x. Epub 2012 Jul 24.
5
Outpatient treatment of infantile hemangiomas with propranolol: a prospective study.普萘洛尔门诊治疗婴幼儿血管瘤：一项前瞻性研究。
Actas Dermosifiliogr. 2012 Nov;103(9):806-15. doi: 10.1016/j.ad.2012.01.017. Epub 2012 Jun 23.
6
Treatment with propranolol for infantile hemangioma in 13 Taiwanese newborns and young infants.采用普萘洛尔治疗 13 例台湾新生儿和婴儿的婴幼儿血管瘤。
Pediatr Neonatol. 2012 Apr;53(2):125-32. doi: 10.1016/j.pedneo.2012.01.010. Epub 2012 Mar 3.
7
Propranolol therapy in 55 infants with infantile hemangioma: dosage, duration, adverse effects, and outcome.55例婴儿血管瘤患儿的普萘洛尔治疗：剂量、疗程、不良反应及结局
Pediatr Dermatol. 2011 Nov-Dec;28(6):640-644. doi: 10.1111/j.1525-1470.2011.01569.x. Epub 2011 Oct 13.
8
Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study.普萘洛尔与泼尼松治疗婴儿血管瘤的回顾性对照研究
Pediatr Dermatol. 2011 Nov-Dec;28(6):649-654. doi: 10.1111/j.1525-1470.2011.01551.x. Epub 2011 Oct 13.
9
Haemangioma of infancy: two case reports with an overdose of propranolol.婴儿血管瘤：两例普萘洛尔过量病例报告
Case Rep Dermatol. 2011 Jan;3(1):18-21. doi: 10.1159/000324421. Epub 2011 Feb 5.
10
Oral propranolol as a new treatment for facial infantile hemangioma: case report.口服普萘洛尔作为治疗面部婴幼儿血管瘤的新方法：病例报告
Arq Bras Oftalmol. 2011 May-Jun;74(3):207-8. doi: 10.1590/s0004-27492011000300012.

普萘洛尔用于治疗复杂型婴儿血管瘤：关于治疗开始前预评估现行指南及护理标准的文献综述

Propranolol in use for treatment of complex infant hemangiomas: literature review regarding current guidelines for preassessment and standards of care before initiation of therapy.

作者信息

Fette Andreas

机构信息

Medical School, University of Pécs, Hungary.

出版信息

ScientificWorldJournal. 2013 May 20;2013:850193. doi: 10.1155/2013/850193. Print 2013.

DOI:10.1155/2013/850193
PMID:23766715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3673324/
Abstract

In 2008, the positive effects of propranolol on infantile hemangiomas (IH) have been discovered serendipitously by Léauté-Labrèze and her coworkers. Since then, propranolol has been in use in allday clinical practice worldwide for treatment of IH. It even caused some kind of paradigm shift in the overall management of these lesions, though propranolol is still not FDA approved, respectively, in "off-label" use for this indication in the majority of institutions. Thus, the aim of this communication is to evaluate the literature for current evidence regarding guidelines for preassessment and standards of care before initiation of therapy.

摘要

2008年，勒奥特 - 拉布雷兹及其同事意外发现了普萘洛尔对婴儿血管瘤（IH）的积极作用。从那时起，普萘洛尔在全球范围内的日常临床实践中一直用于治疗IH。尽管普萘洛尔仍未获得美国食品药品监督管理局（FDA）的批准，在大多数机构中属于该适应症的“超说明书”用药，但它甚至在这些病变的整体管理中引起了某种范式转变。因此，本交流的目的是评估文献，以获取有关治疗开始前预评估指南和护理标准的当前证据。