Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.
Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):161-9. doi: 10.1016/j.plefa.2010.06.003. Epub 2010 Jul 14.
The role of fatty acids (FA) in prostate carcinogenesis is unclear. Interest in the inter-relationship among different types of FA has resulted in new analytic approaches to FA and their role in cancer development. We evaluated the association between erythrocyte FA and prostate cancer in 127 prostate cancer patients and 183 screen negative controls. We present three approaches to the analyses of the FA and prostate cancer association; (1) individual or common groups of FA, (2) biologically meaningful FA ratios and (3) principal components analysis. Monounsaturated FA and the alpha-linolenic:eicosapentaenoic ratio were associated with reduced risk of prostate cancer. However, Factor 1, which was strongly correlated with some long chain saturated FA, was associated with an increased risk of prostate cancer. We provide an example of modeling FA and their inter-relationships on the risk of prostate cancer. Comparing three approaches suggests the importance of considering the impact of the entire fatty acid profile in disease prevention.
脂肪酸（FA）在前列腺癌发生中的作用尚不清楚。人们对不同类型 FA 之间的相互关系产生了兴趣，这导致了 FA 的新分析方法及其在癌症发展中的作用。我们评估了 127 例前列腺癌患者和 183 例筛查阴性对照者的红细胞 FA 与前列腺癌之间的关系。我们提出了三种分析 FA 与前列腺癌关系的方法：（1）单个或常见的 FA 组，（2）有生物学意义的 FA 比值，（3）主成分分析。单不饱和脂肪酸和α-亚麻酸：二十碳五烯酸比值与前列腺癌风险降低相关。然而，与一些长链饱和 FA 强烈相关的因子 1 与前列腺癌风险增加相关。我们提供了一个关于 FA 及其相互关系对前列腺癌风险建模的例子。比较三种方法表明，在疾病预防中考虑整个脂肪酸谱的影响非常重要。
