Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China.
Org Lett. 2013 Jul 5;15(13):3354-7. doi: 10.1021/ol401404y. Epub 2013 Jun 14.
An unprecedented protocol for the copper-mediated direct cyanation of aryl C-H by employing 2,2'-azobisisobutyronitrile (AIBN) as a free radical "CN" source is presented. The protocol not only provides a more efficient pathway for the synthesis of aryl nitriles in terms of the yields and the loading amount of copper salts but also, more importantly, represents a novel strategy for aryl C-H cyanation via a CN free-radical mechanism as compared to the CN anion-participating protocols often reported.
本文提出了一种前所未有的铜介导的芳基 C-H 直接氰化反应的协议，该协议采用 2,2'-偶氮二异丁腈（AIBN）作为自由基“CN”源。该协议不仅在产率和铜盐的负载量方面为芳基腈的合成提供了更有效的途径，而且更重要的是，与通常报道的 CN 阴离子参与的协议相比，该协议代表了通过 CN 自由基机制进行芳基 C-H 氰化的新策略。
