铜催化 N-对甲苯磺酰腙与硫氰酸盐盐作为“CN”源的氰化反应。
Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the "CN" Source.
机构信息
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
出版信息
J Org Chem. 2017 Jul 21;82(14):7621-7627. doi: 10.1021/acs.joc.7b00836. Epub 2017 Jul 10.
PMID:28656758
Abstract
A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.
摘要
一种通过 N-对甲苯磺酰腙的铜催化氰化反应，以硫氰酸盐作为氰源，成功实现α-芳基腈合成的新方法。该方法的特点包括操作方便、底物易得、毒性低的硫氰酸盐盐以及广泛的底物范围。
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