Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
J Org Chem. 2017 Jul 21;82(14):7621-7627. doi: 10.1021/acs.joc.7b00836. Epub 2017 Jul 10.
A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.
一种通过 N-对甲苯磺酰腙的铜催化氰化反应，以硫氰酸盐作为氰源，成功实现α-芳基腈合成的新方法。该方法的特点包括操作方便、底物易得、毒性低的硫氰酸盐盐以及广泛的底物范围。
