镍催化的苯胺炔环化反应：通过 C-H/N-H 官能化实现多功能吲哚合成。
Nickel-catalyzed alkyne annulation by anilines: versatile indole synthesis by C-H/N-H functionalization.
机构信息
Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany.
出版信息
Chem Commun (Camb). 2013 Jul 28;49(59):6638-40. doi: 10.1039/c3cc43915a.
PMID:23770772
Abstract
Versatile nickel catalysts enabled the step-economical synthesis of decorated indoles through alkyne annulations with anilines bearing removable directing groups. The C-H/N-H activation strategy efficiently occurred in the absence of any metal oxidants and with excellent selectivities.
摘要
多功能镍催化剂通过带有可去除导向基团的苯胺与炔烃的环加成反应，实现了具有装饰性的吲哚的分步经济性合成。在没有任何金属氧化剂的情况下，通过 C-H/N-H 活化策略有效地发生反应，并具有优异的选择性。
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