Department of Chemistry, Nanchang University, Nanchang 330031, China.
Langmuir. 2013 Jul 16;29(28):8929-35. doi: 10.1021/la401887b. Epub 2013 Jun 28.
Utilizing the principles of metal-ion-mediated base pairs (C-Ag-C and T-Hg-T), the pH-sensitive conformational transition of C-rich DNA strand, and the ligand-exchange process triggered by DL-dithiothreitol (DTT), a system of colorimetric logic gates (YES, AND, INHIBIT, and XOR) can be rationally constructed based on the aggregation of the DNA-modified Au NPs. The proposed logic operation system is simple, which consists of only T-/C-rich DNA-modified Au NPs, and it is unnecessary to exquisitely design and alter the DNA sequence for different multiple molecular logic operations. The nonnatural base pairing combined with unique optical properties of Au NPs promises great potential in multiplexed ion sensing, molecular-scale computers, and other computational logic devices.
利用金属离子介导的碱基对（C-Ag-C 和 T-Hg-T）、富含 C 的 DNA 链的 pH 敏感构象转变以及 DL-二硫苏糖醇（DTT）引发的配体交换过程，可以基于 DNA 修饰的 Au NPs 的聚集来合理构建比色逻辑门（YES、AND、INHIBIT 和 XOR）系统。所提出的逻辑运算系统简单，仅由富含 T/C 的 DNA 修饰的 Au NPs 组成，并且不需要为不同的多种分子逻辑运算精巧地设计和改变 DNA 序列。非天然碱基配对结合 Au NPs 的独特光学性质，有望在多重离子传感、分子尺度计算机和其他计算逻辑设备中具有巨大的潜力。
