通过膳食癌症预防化合物靶向表观遗传学预防癌症——以 miRNA 为例。
Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA.
机构信息
Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, Piscataway, NJ 08854, USA.
出版信息
Cancer Prev Res (Phila). 2013 Jul;6(7):622-4. doi: 10.1158/1940-6207.CAPR-13-0202. Epub 2013 Jun 17.
Abstract
In cancer, genetic mutations have long been considered to be the only driver of neoplasia. However, there is increasing evidence that epigenetic alterations could also play a major role in carcinogenesis and cancer. A number of experimental and epidemiologic studies have shown that many classes of dietary phytochemicals possess cancer-preventive and epigenetic-modifying properties. The report by Derry and colleagues in this issue of the journal shows that grape seed extract (GSE) prevents azoxymethane (AOM)-induced colon colitis via epigenetic microRNA (miRNA) regulation. Although the precise mechanism underlying the control of miRNA expression is not well understood currently, epigenetic changes could play a major role. This report, along with increasing evidence showing the impact of dietary phytochemicals on epigenetic activities, offers new perspectives on miRNA and epigenetic regulation in cancer prevention.
摘要
在癌症中，基因突变长期以来一直被认为是肿瘤发生的唯一驱动因素。然而，越来越多的证据表明，表观遗传改变也可能在癌症发生和发展中发挥重要作用。许多实验和流行病学研究表明，许多类别的膳食植物化学物质具有预防癌症和表观遗传修饰的特性。Derry 及其同事在本期杂志上的报告表明，葡萄籽提取物（GSE）通过表观遗传 microRNA（miRNA）调控预防氧化偶氮甲烷（AOM）诱导的结肠结肠炎。尽管目前对 miRNA 表达调控的精确机制尚不完全清楚，但表观遗传变化可能起主要作用。这一报告以及越来越多的证据表明膳食植物化学物质对表观遗传活性的影响，为 miRNA 和癌症预防中的表观遗传调控提供了新的视角。
相似文献
1
Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA.
Cancer Prev Res (Phila). 2013 Jul;6(7):622-4. doi: 10.1158/1940-6207.CAPR-13-0202. Epub 2013 Jun 17.
2
Grape seeds: ripe for cancer chemoprevention.
Cancer Prev Res (Phila). 2013 Jul;6(7):617-21. doi: 10.1158/1940-6207.CAPR-13-0193. Epub 2013 Jun 14.
3
Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Cancer Prev Res (Phila). 2013 Jul;6(7):625-33. doi: 10.1158/1940-6207.CAPR-13-0053. Epub 2013 May 2.
4
Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis.
BMC Complement Altern Med. 2016 Aug 9;16:278. doi: 10.1186/s12906-016-1254-2.
5
Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats.
Mol Carcinog. 2010 Jul;49(7):641-52. doi: 10.1002/mc.20643.
6
Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2.
Br J Nutr. 2010 Sep;104(6):824-32. doi: 10.1017/S0007114510001522. Epub 2010 Jun 14.
7
Characterization of azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy.
Exp Toxicol Pathol. 2014 Aug;66(5-6):235-42. doi: 10.1016/j.etp.2014.02.003. Epub 2014 Mar 23.
8
Emu oil and grape seed extract reduce tumour burden and disease parameters in murine colitis-associated colorectal cancer.
Carcinogenesis. 2021 Feb 25;42(2):202-209. doi: 10.1093/carcin/bgaa099.
9
Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds.
Nutrition. 2014 Nov-Dec;30(11-12):1242-56. doi: 10.1016/j.nut.2014.02.016. Epub 2014 Mar 12.
10
MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer.
J Nutr Biochem. 2016 Aug;34:118-25. doi: 10.1016/j.jnutbio.2016.05.003. Epub 2016 May 20.
引用本文的文献
1
In Search of Panacea-Review of Recent Studies Concerning Nature-Derived Anticancer Agents.
Nutrients. 2019 Jun 25;11(6):1426. doi: 10.3390/nu11061426.
2
Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach.
EPMA J. 2018 Nov 12;9(4):403-419. doi: 10.1007/s13167-018-0154-6. eCollection 2018 Dec.
3
Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
Am J Chin Med. 2018 Oct 4:1-15. doi: 10.1142/S0192415X18500829.
4
The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells.
J Cell Biochem. 2018 Nov;119(11):9573-9582. doi: 10.1002/jcb.27275. Epub 2018 Aug 20.
5
Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins.
Diseases. 2016 Apr 28;4(2):21. doi: 10.3390/diseases4020021.
6
Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression.
Curr Genomics. 2017 Apr;18(2):175-205. doi: 10.2174/1389202917666160803165229.
7
HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells.
Cancer Genomics Proteomics. 2017 Jan 2;14(1):17-33. doi: 10.21873/cgp.20016.
8
Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer.
Pathol Oncol Res. 2015 Sep;21(4):921-7. doi: 10.1007/s12253-015-9917-8. Epub 2015 Mar 6.
9
Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines.
Cell Mol Neurobiol. 2015 Mar;35(2):175-87. doi: 10.1007/s10571-014-0109-y. Epub 2014 Sep 12.
10
Epigenetic regulation of miRNA-cancer stem cells nexus by nutraceuticals.
Mol Nutr Food Res. 2014 Jan;58(1):79-86. doi: 10.1002/mnfr.201300528. Epub 2013 Nov 24.
本文引用的文献
1
Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Cancer Prev Res (Phila). 2013 Jul;6(7):625-33. doi: 10.1158/1940-6207.CAPR-13-0053. Epub 2013 May 2.
2
Colitis-accelerated colorectal cancer and metabolic dysregulation in a mouse model.
Carcinogenesis. 2013 Aug;34(8):1861-9. doi: 10.1093/carcin/bgt135. Epub 2013 Apr 24.
3
Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity.
Leukemia. 2013 Dec;27(12):2341-50. doi: 10.1038/leu.2013.94. Epub 2013 Mar 29.
4
Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis.
Epigenetics. 2013 Feb;8(2):220-8. doi: 10.4161/epi.23605. Epub 2013 Jan 16.
5
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas.
Cancer Cell. 2012 Oct 16;22(4):506-523. doi: 10.1016/j.ccr.2012.09.003.
6
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3101-10. doi: 10.1073/pnas.1209100109. Epub 2012 Oct 15.
7
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.
Pharmacol Ther. 2013 Feb;137(2):153-71. doi: 10.1016/j.pharmthera.2012.09.008. Epub 2012 Oct 3.
8
Hallmarks of cancer: of all cancer cells, all the time?
Trends Mol Med. 2012 Sep;18(9):509-15. doi: 10.1016/j.molmed.2012.06.005. Epub 2012 Jul 13.
9
Cancer genetics and epigenetics: two sides of the same coin?
Cancer Cell. 2012 Jul 10;22(1):9-20. doi: 10.1016/j.ccr.2012.06.008.
10
Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators.
Toxicol Appl Pharmacol. 2012 Aug 15;263(1):122-30. doi: 10.1016/j.taap.2012.06.013. Epub 2012 Jun 27.
Zotero 插件