术前用药对恒河猴和人类食管下高压区及反流状态的影响。
The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man.
作者信息
Hall A W, Moossa A R, Clark J, Cooley G R, Skinner D B
出版信息
Gut. 1975 May;16(5):347-52. doi: 10.1136/gut.16.5.347.
Abstract
Thirty-five human volunteers and eight Rhesus monkeys were studied with standard gastrooesophageal manometric techniqes and their reflux status was evaluated witha pH probe placed in the lower oesophagus. morphine sulphate, pethidine hydrochloride, or idazepam was given intravenously until drowsiness was induced. The manometric and pH studies were repeated. All three drugs decreased the lower oesophageal high pressure zone and increased the probability of relux in both monkeys and man. Thes findings are relevant in the preparation of patients for surgery since gastrooesophageal reflux and pulmonary aspiration may be a problen in the pre-and postoperative phases.
摘要
对35名人类志愿者和8只恒河猴采用标准的胃食管测压技术进行研究，并通过将pH探头置于食管下部来评估其反流状态。静脉注射硫酸吗啡、盐酸哌替啶或地西泮，直至引起嗜睡。重复进行测压和pH研究。所有这三种药物均降低了食管下高压区，并增加了猴子和人类反流的可能性。这些发现与患者手术准备相关，因为胃食管反流和肺误吸在术前和术后阶段可能是个问题。
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