抗坏血酸和抗坏血酸钠对1,2 - 二甲基肼和二丙酸雌二醇诱导的CBA小鼠子宫肉瘤发生促进阶段的修饰作用。
Modifying effect of ascorbic acid and sodium ascorbate on the promoting stage of uterine sarcomogenesis induced in CBA mice by 1,2-dimethylhydrazine and estradiol-dipropionate.
作者信息
Turusov V S, Trukhanova L S
机构信息
Institute of Carcinogenesis, USSR Academy of Medical Sciences, Moscow.
出版信息
Cancer Lett. 1991 Jan;56(1):29-35. doi: 10.1016/0304-3835(91)90190-s.
Administration of estradiol-dipropionate (EP) after the cessation of 1,2-dimethylhydrazine (DMH) treatment increased the incidence of uterine sarcomas in CBA mice from 32.5 (DMH alone) to 62.5%. Ascorbic acid (AA) (0.3% in drinking water) given simultaneously with EP decreased the tumour incidence to 35%. Sodium ascorbate did not exert an inhibiting effect. AA inhibited the increase of uterine weight produced in mice by EP and did not influence the growth of mouse transplantable uterine sarcomas. The mechanisms of the antiestrogenic effects of AA are discussed.
在1,2 - 二甲基肼（DMH）治疗停止后给予二丙酸雌二醇（EP），使CBA小鼠子宫肉瘤的发生率从32.5%（仅用DMH时）增加到62.5%。与EP同时给予抗坏血酸（AA）（饮用水中含0.3%）可使肿瘤发生率降至35%。抗坏血酸钠没有发挥抑制作用。AA抑制了EP引起的小鼠子宫重量增加，并且不影响小鼠可移植性子宫肉瘤的生长。讨论了AA的抗雌激素作用机制。
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