University of Macau, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Macao, China.
Expert Opin Investig Drugs. 2013 Aug;22(8):981-92. doi: 10.1517/13543784.2013.805202. Epub 2013 Jun 24.
Triterpenoids isolated from Ganoderma lucidum are a class of naturally occurring compounds and structurally highly oxidized lanostanes. Accumulated data show that triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities. A systematic summary and knowledge of future prospects are necessary to facilitate further studies on this species.
This review aims to summarize and analyze the current knowledge on the anti-cancer properties and mechanisms of G. lucidum triterpenoids (GLTs) and discuss the future prospects of the application of GLTs in cancer treatment.
Extensive research over the last 10 years has provided evidence of the anti-cancer activities of GLTs in different stages of carcinogenesis. These activities include cell cycle arrest, induction of apoptosis and autophagy, and suppression of metastasis and angiogenesis. However, the exact molecular mechanisms involved in these processes remain unclear. Androgen receptor, nuclear factor-kappa B, activator protein-1, p53 and 14-3-3 are reportedly involved in the anti-cancer properties of GLTs. Animal models further shed light on the development of GLTs as anti-cancer agents. However, more research and clinical trials are necessary to exploit these compounds.
灵芝中分离得到的三萜类化合物是一类天然存在的化合物，结构高度氧化的羊毛甾烷。积累的数据表明，三萜类化合物具有广泛的抗癌特性，包括抗增殖、抗转移和抗血管生成活性。有必要对这一物种进行系统的总结和未来前景的知识梳理，以促进对该物种的进一步研究。
本综述旨在总结和分析灵芝三萜类化合物（GLTs）的抗癌特性和机制的现有知识，并讨论 GLTs 在癌症治疗中的应用的未来前景。
过去 10 年的广泛研究为 GLTs 在癌变的不同阶段的抗癌活性提供了证据。这些活性包括细胞周期停滞、诱导细胞凋亡和自噬、抑制转移和血管生成。然而，这些过程中涉及的确切分子机制尚不清楚。雄激素受体、核因子-κB、激活蛋白-1、p53 和 14-3-3 据称参与了 GLTs 的抗癌特性。动物模型进一步阐明了 GLTs 作为抗癌剂的发展。然而，需要更多的研究和临床试验来开发这些化合物。
