Neuropsychiatric Research Institute, 120 South 8th Street, Fargo, ND 58103, USA.
Behav Res Ther. 2013 Aug;51(8):512-7. doi: 10.1016/j.brat.2013.05.007. Epub 2013 May 27.
This study sought to empirically derive and validate clinically relevant personality-based subtypes of anorexia nervosa (AN).
Women (N = 116) with full or subthreshold AN completed baseline measures of personality, clinical variables, and eating disorder (ED) symptoms, followed by two weeks of ecological momentary assessment (EMA). A latent profile analysis was conducted to identify personality subtypes, which were compared on baseline clinical variables and EMA variables.
The best-fitting model supported three subtypes: underregulated, overregulated, and low psychopathology. The underregulated subtype (characterized by high Stimulus Seeking, Self-Harm, and Oppositionality) displayed greater baseline ED symptoms, as well as lower positive affect and greater negative affect, self-discrepancy, and binge eating in the natural environment. The overregulated subtype (characterized by high Compulsivity and low Stimulus Seeking) was more likely to have a lifetime obsessive-compulsive disorder diagnosis and exhibited greater perfectionism; levels of negative affect, positive affect, and self-discrepancy in this group were intermediate between the other subtypes. The low psychopathology subtype (characterized by normative personality) displayed the lowest levels of baseline ED symptoms, co-occurring disorders, and ED behaviors measured via EMA.
Findings support the validity of these personality-based subtypes, suggesting the potential utility of addressing within-diagnosis heterogeneity in the treatment of AN.
本研究旨在从实证角度推导出并验证神经性厌食症(AN)的基于人格的临床相关亚型。
有完全或亚阈值 AN 的女性(N=116)完成了人格、临床变量和饮食障碍(ED)症状的基线测量,随后进行了两周的生态瞬时评估(EMA)。进行了潜在剖面分析以确定人格亚型,并比较了基线临床变量和 EMA 变量。
最佳拟合模型支持三种亚型:调节不足、过度调节和低精神病理学。调节不足的亚型(表现为高刺激寻求、自我伤害和对立性)表现出更高的基线 ED 症状,以及更低的积极情绪和更高的消极情绪、自我差异和自然环境中的暴食。过度调节的亚型(表现为高强迫性和低刺激寻求)更有可能有终生强迫症诊断,并表现出更高的完美主义;该组的消极情绪、积极情绪和自我差异水平介于其他亚型之间。低精神病理学亚型(表现为正常人格)表现出最低水平的基线 ED 症状、共病障碍和 EMA 测量的 ED 行为。
研究结果支持这些基于人格的亚型的有效性,表明在治疗 AN 中解决诊断内异质性具有潜在的效用。