Makubi Abel, Okuma James, Spiegelman Donna, Hawkins Claudia, Darling Anne Marie, Jackson Elizabeth, Mugusi Ferdinand, Chalamilla Guerino, Fawzi Wafaie
School of Medicine, Muhimbili University Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania Management and Development for Health, Tanzania
Department of Nutrition, Harvard School of Public Health, USA.
J Int Assoc Provid AIDS Care. 2015 Mar-Apr;14(2):148-55. doi: 10.1177/2325957413488195. Epub 2013 Jun 21.
This cross-sectional study aimed at determining the prevalence and risk factors for severe anemia, severe microcytic anemia, and severe normocytic anemia among HIV-infected individuals aged >15 years. Univariate and multivariate analyses were performed to identify the risk factors for anemia.
Data from 40 408 patients were analyzed, showing an overall prevalence of 22% for severe anemia. The risk of developing severe anemia increased by 49% among patients with a body mass index of <18.5 kg/m(2), by approximately 2-fold among patients with the World Health Organization (WHO) stage III, and by 3-fold among patients with WHO stage IV illness. Severe normocytic anemia was uniquely increased among patients aged ≥50 years, among those with chronic diarrhea and Kaposi's sarcoma, and those taking cotrimoxazole.
There was a high prevalence of severe anemia among adults infected with HIV. Focused identification of anemia should be based on the hemoglobin and mean corpuscular volume measurements.
本横断面研究旨在确定15岁以上HIV感染者中重度贫血、重度小细胞贫血和重度正细胞贫血的患病率及危险因素。进行单因素和多因素分析以确定贫血的危险因素。
对40408例患者的数据进行分析，结果显示重度贫血的总体患病率为22%。体重指数<18.5 kg/m²的患者发生重度贫血的风险增加49%，世界卫生组织（WHO）III期患者增加约2倍，WHO IV期疾病患者增加3倍。重度正细胞贫血在年龄≥50岁的患者、患有慢性腹泻和卡波西肉瘤的患者以及服用复方新诺明的患者中独特增加。
HIV感染成人中重度贫血的患病率很高。应根据血红蛋白和平均红细胞体积测量结果重点识别贫血。
