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拟南芥对乙烯气体的瞬时转录反应驱动生长激素的交叉调控。

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis.

作者信息

Chang Katherine Noelani, Zhong Shan, Weirauch Matthew T, Hon Gary, Pelizzola Mattia, Li Hai, Huang Shao-Shan Carol, Schmitz Robert J, Urich Mark A, Kuo Dwight, Nery Joseph R, Qiao Hong, Yang Ally, Jamali Abdullah, Chen Huaming, Ideker Trey, Ren Bing, Bar-Joseph Ziv, Hughes Timothy R, Ecker Joseph R

机构信息

Plant Biology Laboratory, and Genomic Analysis Laboratory , The Salk Institute for Biological Studies , La Jolla , United States.

出版信息

Elife. 2013 Jun 11;2:e00675. doi: 10.7554/eLife.00675.

DOI:10.7554/eLife.00675
PMID:23795294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3679525/
Abstract

The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways. DOI:http://dx.doi.org/10.7554/eLife.00675.001.

摘要

气态植物激素乙烯调控众多生长和发育过程。乙烯转录反应如何协调众多生长控制途径仍不清楚。我们通过在乙烯处理的时间进程中使用染色质免疫沉淀测序和转录测序，鉴定乙烯信号通路主调控因子乙烯不敏感3（EIN3）的靶标，来表征动态乙烯转录反应。乙烯诱导的转录发生在由EIN3调控的时间波中，表明存在不同层次的转录控制。发现EIN3结合可调节众多下游转录级联反应，包括乙烯信号通路的主要反馈调节电路，以及整合大多数激素介导的生长反应途径之间的众多联系。这些发现以新的方式提供了将每个主要植物生长和发育网络联系起来的直接证据。DOI:http://dx.doi.org/10.7554/eLife.00675.001

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