Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.
Trends Microbiol. 2013 Aug;21(8):389-96. doi: 10.1016/j.tim.2013.05.006. Epub 2013 Jun 21.
The invasion and stimulation of normally non-phagocytic host cells, such as epithelial and endothelial cells, is a key step in the pathogenesis of many fungal infections. In most cases, host cell invasion and/or stimulation of a proinflammatory response is induced when proteins or carbohydrates on the fungal cell surface bind to receptors on the host cell. Although many of these fungal-host cell interactions have only been investigated in vitro, the therapeutic efficacy of blocking the host cell receptors for Candida albicans and Rhizopus oryzae has been demonstrated in experimental animal models of infection. We summarize recent studies of the fungal receptors on normally non-phagocytic host cells and the therapeutic implications of blocking these receptors.
通常情况下，真菌并不会侵入非吞噬性的宿主细胞，例如上皮细胞和内皮细胞。然而，这种情况却是许多真菌感染的发病机制中的关键步骤。在大多数情况下，真菌细胞表面的蛋白质或碳水化合物与宿主细胞表面的受体结合时，就会引发宿主细胞的入侵和/或促炎反应。尽管这些真菌-宿主细胞的相互作用仅在体外进行了研究，但在念珠菌和根霉感染的实验动物模型中，阻断宿主细胞受体的治疗效果已经得到了证实。我们总结了最近关于非吞噬性宿主细胞上的真菌受体的研究，并探讨了阻断这些受体的治疗意义。
