Clinical Laboratory Medicine Department; Attached Hospital of Jining Medical College; Shandong, Jining P.R. China.
Hum Vaccin Immunother. 2013 Aug;9(8):1739-40. doi: 10.4161/hv.24847. Epub 2013 Jun 4.
A case of acute immune thrombocytopenic purpura following oral polio vaccine (OPV) is reported. An 82-d-old infant developed purpura at the same day after the second dose of oral polio vaccine. Until the time of hospital admission, the male infant had been in good health and had not received any drugs, and the possible causes of this condition were excluded. His platelet count was 13×10(9)/L. Platelet-associated IgG was elevated, but the amount of megakaryocytes in bone marrow aspirates was within the normal range, suggesting immune mechanism-associated thrombocytopenia. The infant recovered with the proper treatment within 30 d. Attention should be paid to OPV-associated thrombocytopenia, though it seems to be less frequent than after natural infections.
现报道 1 例口服脊髓灰质炎减毒活疫苗（OPV）后发生急性免疫性血小板减少性紫癜。1 名 82 日龄婴儿在第 2 剂口服脊髓灰质炎减毒活疫苗后当天出现紫癜。患儿入院前身体状况良好，未使用任何药物，且已排除可能导致该情况的其他原因。其血小板计数为 13×10(9)/L。血小板相关 IgG 升高，但骨髓抽吸物中巨核细胞数量在正常范围内，提示与免疫机制相关的血小板减少症。患儿经适当治疗后 30 d 内康复。虽然 OPV 相关血小板减少症似乎比自然感染后少见，但仍需注意。
