Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Am J Emerg Med. 2013 Aug;31(8):1264-7. doi: 10.1016/j.ajem.2013.05.029. Epub 2013 Jul 1.
The objective of this study was to review all cases in literature in which the clinical manifestations of myasthenia gravis (MG) and Guillain-Barré syndrome (GBS) were presented in the same patient including a new case of our own and identify the clinical characteristics and possible mechanisms of this syndrome.
We reviewed 12 reports in which 13 cases were diagnosed as MG and GBS. The clinical manifestations of the 13 cases and our new case were analyzed in detail to show the characteristics of this kind of syndrome.
Of all the cases, 5 females and 9 males, 6 of them were Chinese; 3 were Americans; 3 were Israelis; 1 was white and one was a Frenchman. The age of seven patients was no more than 45 years old. They all had the symptoms of extrocular muscle weakness. Nerve conduction and RNS abnormal were seen in all tested cases. Acetylcholine receptor antibody was positive in all tested patients. Prognosis was good in 8 of the 11 recorded patients.
Although extremely rare, MG and GBS may present in the same patient with variant characteristics. The typical clinical characteristics of GBS and MG may be helpful for the diagnosis of future possible cases.
本研究旨在回顾文献中所有表现为重症肌无力（MG）和格林-巴利综合征（GBS）的临床表现的病例，包括我们自己的一个新病例，并确定该综合征的临床特征和可能的机制。
我们回顾了 12 份报告，其中有 13 例被诊断为 MG 和 GBS。详细分析了这 13 例病例和我们的新病例的临床表现，以显示这种综合征的特征。
所有病例中，女性 5 例，男性 9 例，其中 6 例为中国人；3 例为美国人；3 例为以色列人；1 例为白人，1 例为法国人。7 名患者的年龄均不超过 45 岁。他们均有眼外肌无力的症状。所有检测病例均出现神经传导和 RNS 异常。所有检测患者的乙酰胆碱受体抗体均为阳性。11 例记录患者中有 8 例预后良好。
尽管极为罕见，但 MG 和 GBS 可能以不同的特征表现为同一患者。GBS 和 MG 的典型临床特征可能有助于诊断未来可能出现的病例。
