Kung Sheng-Ling, Su Jang-Ming, Tsai Shin-Jei, Lu Tsong-Ming, Chen Chiu-Mei
Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Acta Neurol Taiwan. 2009 Sep;18(3):193-7.
The concurrent development of Guillain-Barré syndrome (GBS) and myasthenia gravis (MG) is rare. It has been associated with molecular mimicry between infectious agents and self-antigens. Such antibodies may show cross-reactions against both myelin proteins of peripheral nerves and acetylcholine receptors of neuromuscular junctions. Thymoma-associated multi-organ autoimmunity may also play a role in initiating autoimmune process. We present such a case with the concurrent development of GBS and MG.
吉兰-巴雷综合征（GBS）和重症肌无力（MG）同时发生的情况较为罕见。它与感染因子和自身抗原之间的分子模拟有关。此类抗体可能会对外周神经的髓鞘蛋白和神经肌肉接头的乙酰胆碱受体产生交叉反应。胸腺瘤相关的多器官自身免疫也可能在启动自身免疫过程中发挥作用。我们在此呈现这样一例GBS和MG同时发生的病例。
