Collinger Jennifer L, Foldes Stephen, Bruns Tim M, Wodlinger Brian, Gaunt Robert, Weber Douglas J
Department of Veterans Affairs, Pittsburgh, PA 15206, USA.
J Spinal Cord Med. 2013 Jul;36(4):258-72. doi: 10.1179/2045772313Y.0000000128.
Spinal cord injury (SCI) results in a loss of function and sensation below the level of the lesion. Neuroprosthetic technology has been developed to help restore motor and autonomic functions as well as to provide sensory feedback.
This paper provides an overview of neuroprosthetic technology that aims to address the priorities for functional restoration as defined by individuals with SCI. We describe neuroprostheses that are in various stages of preclinical development, clinical testing, and commercialization including functional electrical stimulators, epidural and intraspinal microstimulation, bladder neuroprosthesis, and cortical stimulation for restoring sensation. We also discuss neural recording technologies that may provide command or feedback signals for neuroprosthetic devices.
CONCLUSION/CLINICAL RELEVANCE: Neuroprostheses have begun to address the priorities of individuals with SCI, although there remains room for improvement. In addition to continued technological improvements, closing the loop between the technology and the user may help provide intuitive device control with high levels of performance.
脊髓损伤（SCI）会导致损伤平面以下的功能和感觉丧失。神经假体技术已被开发出来，以帮助恢复运动和自主功能，并提供感觉反馈。
本文概述了旨在解决脊髓损伤患者所确定的功能恢复优先事项的神经假体技术。我们描述了处于临床前开发、临床试验和商业化各个阶段的神经假体，包括功能性电刺激器、硬膜外和脊髓内微刺激、膀胱神经假体以及用于恢复感觉的皮层刺激。我们还讨论了可能为神经假体设备提供命令或反馈信号的神经记录技术。
结论/临床意义：神经假体已开始解决脊髓损伤患者的优先事项，尽管仍有改进空间。除了持续的技术改进外，缩小技术与用户之间的差距可能有助于提供具有高性能的直观设备控制。
