ROS 为巨噬细胞分化奠定了基础。
ROS sets the stage for macrophage differentiation.
机构信息
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Cell Res. 2013 Aug;23(8):984-5. doi: 10.1038/cr.2013.88. Epub 2013 Jul 9.
Abstract
While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.
摘要
虽然 M1 巨噬细胞具有高度的促炎和杀菌作用，但 M2 巨噬细胞和相关的肿瘤相关巨噬细胞（TAMs）调节组织重塑和血管生成，并具有免疫调节活性。在《细胞研究》7 月刊上，Zhang 等人表明，ROS 产生对于 M1 巨噬细胞的激活和功能至关重要，对于 M2 巨噬细胞和 TAMs 的分化也是必需的，抗氧化治疗可阻断 TAMs 的分化和癌症小鼠模型中的肿瘤发生。
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