Tang Jen-Yang, Lee Jin-Ching, Chang Yung-Ting, Hou Ming-Feng, Huang Hurng-Wern, Liaw Chih-Chuang, Chang Hsueh-Wei
Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
ScientificWorldJournal. 2013 Jun 6;2013:943539. doi: 10.1155/2013/943539. Print 2013.
Long noncoding RNA (lncRNA) function is described in terms of related gene expressions, diseases, and cancers as well as their polymorphisms. Potential modulators of lncRNA function, including clinical drugs, natural products, and derivatives, are discussed, and bioinformatic resources are summarized. The improving knowledge of the lncRNA regulatory network has implications not only in gene expression, diseases, and cancers, but also in the development of lncRNA-based pharmacology.
长链非编码RNA（lncRNA）的功能是根据相关基因表达、疾病、癌症及其多态性来描述的。文中讨论了lncRNA功能的潜在调节剂，包括临床药物、天然产物和衍生物，并总结了生物信息学资源。对lncRNA调控网络认识的不断深入不仅对基因表达、疾病和癌症有影响，而且对基于lncRNA的药理学发展也有影响。
