Wound Healing Research Unit, Cardiff University, Cardiff, United Kingdom.
PLoS One. 2013 Jul 2;8(7):e67083. doi: 10.1371/journal.pone.0067083. Print 2013.
Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs).
To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing.
685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis.
Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002).
The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.
静脉性腿部溃疡很常见，令人困扰，其无法愈合通常与沉重的生物负担有关。离子银具有抗炎和抗菌特性。释放银离子的泡沫敷料比优碘银在四项随机对照试验（RCT）中已被证实具有促进溃疡愈合的作用。
通过meta 分析方法评估使用比优碘银或非活性敷料治疗后的溃疡愈合情况。
共有 685 名单纯或混合性难以愈合的静脉性腿部溃疡患者纳入该 meta 分析。
比优碘银显示出显著的治疗效果（p<0.0001）、应答率（p<0.001）和愈合率（p = 0.002）。
四项 RCT 的 meta 分析提供了统计上显著的证据，支持在治疗难以愈合的静脉性腿部溃疡时使用比优碘银敷料。
Zotero 插件