Bruera E, Legris M A, Kuehn N, Miller M J
J Pain Symptom Manage. 1990 Aug;5(4):218-20. doi: 10.1016/0885-3924(90)90014-b.
Fifty-eight consecutive patients with advanced cancer who required parenteral hydration were treated with hypodermoclysis. A solution of two-thirds 5% dextrose and one-third saline was used in all cases at a rate of 20-100 cc/hr, with 750 units of hyaluronidase per liter, and 20-40 mEq KCl/L were administered in all patients. In 38 patients, morphine (21 cases) or hydromorphone (17 cases) were added. The mean duration of infusion and volume were 14 +/- 9 days and 1.3 +/- 0.8 L/day, respectively (range, 0.5-3 L/day). Mean dose of KCl was 25 +/- 8 mEq/L. The reason for discontinuation was death in 43 cases, oral hydration in 12 cases, and need for fluid restriction in 3 cases. Toxicity consisted in local infection in two cases and bruising in two cases. We conclude that hypodermoclysis is a safe and effective method of hydration in patients with advanced cancer.
58例连续的晚期癌症患者需要胃肠外补液，接受了皮下输液治疗。所有病例均使用三分之二的5%葡萄糖和三分之一的生理盐水溶液，速率为20 - 100毫升/小时，每升溶液含750单位透明质酸酶，所有患者均给予20 - 40毫当量氯化钾/升。38例患者中，添加了吗啡（21例）或氢吗啡酮（17例）。平均输注持续时间和容量分别为14±9天和1.3±0.8升/天（范围为0.5 - 3升/天）。氯化钾的平均剂量为25±8毫当量/升。停药原因是43例患者死亡，12例患者改为口服补液，3例患者需要限制液体摄入。毒性反应包括2例局部感染和2例瘀伤。我们得出结论，皮下输液是晚期癌症患者安全有效的补液方法。
