Tsai Tsung-Han, Potsaid Benjamin, Tao Yuankai K, Jayaraman Vijaysekhar, Jiang James, Heim Peter J S, Kraus Martin F, Zhou Chao, Hornegger Joachim, Mashimo Hiroshi, Cable Alex E, Fujimoto James G
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biomed Opt Express. 2013 Jun 14;4(7):1119-32. doi: 10.1364/BOE.4.001119. Print 2013 Jul 1.
We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.
我们开发了一种外径为3.2毫米的基于微电机的微型导管，用于超高速内窥扫频源光学相干断层扫描（OCT），该扫描使用垂直腔面发射激光器（VCSEL），轴向扫描速率为1兆赫兹。该微电机能够以每秒数百帧的速度旋转一个微棱镜，驱动电压低于5伏，以提供快速且稳定的扫描，并且对导管的弯曲不敏感。侧视探头可以拉回以获取覆盖标本大面积的三维（3D）数据集。VCSEL提供高轴向扫描速率，以支持高帧率操作下的密集采样。使用高速数据采集系统，展示了在兔胃肠道中的体内3D-OCT成像以及对人类结肠标本的离体成像，其轴向分辨率为8微米，横向分辨率为8微米，组织深度范围为1.2毫米，帧率为400帧/秒。
