A low-power integrated bioamplifier with active low-frequency suppression.

We present in this paper a low-power bioamplifier suitable for massive integration in dense multichannel recording devices. This bioamplifier achieves reduced-size compared to previous designs by means of active low-frequency suppression. An active integrator located in the feedback path of a low-noise amplifier is employed for placing a highpass cutoff frequency within the transfer function. A very long integrating time constant is achieved using a small integrated capacitor and a MOS-bipolar equivalent resistor. This configuration rejects unwanted low-frequency contents without the need for input RC networks or large feedback capacitors. Therefore, the bioamplifier high-input impedance and small size are preserved. The bioamplifier, implemented in a 0.18-mum CMOS process, has been designed for neural recording of action potentials, and optimised through a transconductance-ef-ficiency design methodology for micropower operation. Measured performance and results obtained from in vivo recordings are presented. The integrated bioamplifier provides a midband gain of 50 dB, and achieves an input-referred noise of 5.6 muVrms. It occupies less than 0.050 mm(2) of chip area and dissipates 8.6 muW.