Zoology Department, Cairo University, Giza, Egypt.
Eur Rev Med Pharmacol Sci. 2013 Jul;17(13):1782-8.
The use of mobile phones is rapidly increasing all over the world. Few studies deal with the effect of electromagnetic radiation (EMR) on monoamine neurotransmitters in the different brain areas of adult rat.
The aim of the present study was to investigate the effect of EMR on the concentrations of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) in the hippocampus, hypothalamus, midbrain and medulla oblongata of adult rats.
Adult rats were exposed daily to EMR (frequency 1800 MHz, specific absorption rate 0.843 W/kg, power density 0.02 mW/cm2, modulated at 217 Hz) and sacrificed after 1, 2 and 4 months of daily EMR exposure as well as after stopping EMR for 1 month (after 4 months of daily EMR exposure). Monoamines were determined by high performance liquid chromatography coupled with fluorescence detection (HPLC-FD) using their native properties.
The exposure to EMR resulted in significant changes in DA, NE and 5-HT in the four selected areas of adult rat brain.
The exposure of adult rats to EMR may cause disturbances in monoamine neurotransmitters and this may underlie many of the adverse effects reported after EMR including memory, learning, and stress.
手机在全球范围内的使用正在迅速增加。很少有研究涉及电磁辐射（EMR）对成年大鼠不同大脑区域中单胺神经递质的影响。
本研究旨在探讨 EMR 对成年大鼠海马体、下丘脑、中脑和延髓中单胺递质多巴胺（DA）、去甲肾上腺素（NE）和 5-羟色胺（5-HT）浓度的影响。
成年大鼠每天接受 EMR（频率 1800 MHz，比吸收率 0.843 W/kg，功率密度 0.02 mW/cm2，调制频率为 217 Hz）照射，分别在每天 EMR 照射 1、2 和 4 个月以及停止 EMR 照射 1 个月（即每天 EMR 照射 4 个月后）后处死。采用高效液相色谱-荧光检测法（HPLC-FD）根据其固有特性测定单胺类物质。
EMR 暴露导致成年大鼠大脑四个选定区域的 DA、NE 和 5-HT 发生显著变化。
成年大鼠暴露于 EMR 可能会导致单胺神经递质紊乱，这可能是 EMR 引起的许多不良反应的基础，包括记忆、学习和压力。
