1 Department of Oral and Maxillofacial Surgery, National Dental Centre Singapore , Singapore, Singapore .
Tissue Eng Part B Rev. 2014 Apr;20(2):147-62. doi: 10.1089/ten.TEB.2013.0131. Epub 2013 Aug 28.
Despite significant surgical advances over the last decades, segmental mandibular bone repair remains a challenge. In light of this, tissue engineering might offer a next step in the evolution of mandibular reconstruction.
The purpose of the present report was to (1) systematically review preclinical in vivo as well as clinical literature regarding bone tissue engineering for mandibular continuity defects, and (2) to analyze their effectiveness.
An electronic search in the databases of the National Library of Medicine and ISI Web of Knowledge was carried out. Only publications in English were considered, and the search was broadened to animals and humans. Furthermore, the reference lists of related review articles and publications selected for inclusion in this review were systematically screened. Results of histology data and amount of bone bridging were chosen as primary outcome variables. However, for human reports, clinical radiographic evidence was accepted for defined primary outcome variable. The biomechanical properties, scaffold degradation, and clinical wound healing were selected as co-outcome variables.
The electronic search in the databases of the National Library of Medicine and ISI Web of Knowledge resulted in the identification of 6727 and 5017 titles, respectively. Thereafter, title assessment and hand search resulted in 128 abstracts, 101 full-text articles, and 29 scientific papers reporting on animal experiments as well as 11 papers presenting human data on the subject of tissue-engineered reconstruction of mandibular continuity defects that could be included in the present review.
It was concluded that (1) published preclinical in vivo as well as clinical data are limited, and (2) tissue-engineered approaches demonstrate some clinical potential as an alternative to autogenous bone grafting.
尽管过去几十年在外科手术方面取得了重大进展，但节段性下颌骨修复仍然是一个挑战。有鉴于此，组织工程可能是下颌骨重建发展的下一步。
本报告的目的是：（1）系统地回顾关于用于下颌骨连续性缺损的骨组织工程的临床前体内以及临床文献；（2）分析其有效性。
在国家医学图书馆和 ISI Web of Knowledge 数据库中进行了电子搜索。仅考虑英文出版物，并将搜索范围扩大到动物和人类。此外，还系统地筛选了相关综述文章和入选本综述的出版物的参考文献列表。选择组织学数据的结果和骨桥接的量作为主要结局变量。然而，对于人类报告，将临床放射影像学证据作为定义的主要结局变量接受。生物力学特性、支架降解和临床伤口愈合被选为次要结局变量。
在国家医学图书馆和 ISI Web of Knowledge 数据库中的电子搜索分别确定了 6727 篇和 5017 篇标题。此后，标题评估和手工搜索产生了 128 份摘要、101 篇全文文章和 29 篇科学论文，报道了动物实验，以及 11 篇介绍组织工程重建下颌骨连续性缺损的人类数据的论文，可以纳入本综述。
得出的结论是：（1）已发表的临床前体内和临床数据有限；（2）组织工程方法显示出一些临床潜力，可作为自体骨移植的替代方法。
