Gallhoefer Nicolin S, Bentley Ellison, Ruetten Maja, Grest Paula, Haessig Michael, Kircher Patrick R, Dubielzig Richard R, Spiess Bernhard M, Pot Simon A
Ophthalmology Unit, Equine Department, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.
J Am Vet Med Assoc. 2013 Aug 1;243(3):376-88. doi: 10.2460/javma.243.3.376.
To compare ultrasonographic and histologic examination findings for eyes of animals with ocular diseases.
Retrospective case series.
116 eyes of 113 animals examined at 2 facilities.
Diseased eyes of animals were examined by means of ultrasonography, removed via enucleation or exenteration, then histologically examined. Ultrasonographic images and histopathologic slides were evaluated, and diseases of eyes were identified with each of those methods and allocated to various categories. For each disease category, agreement between results of ultrasonography and those of histologic examination was assessed via determination of κ statistic values.
Tests had good agreement for identification of iris or ciliary body neoplasia. Overall, intraocular neoplasia was not detected via ultrasonography for only 2 of 31 eyes with histologically detected neoplasia. Hemorrhagic or inflammatory changes were misinterpreted as neoplasia for 8 of 37 (22%) eyes. Tests had moderate to acceptable agreement for identification of retinal detachment. Retinal detachment was not detected by means of ultrasonography for 14 of 38 (37%) eyes with that diagnosis determined via histologic examination at one of the facilities (primarily in eyes with intraocular hemorrhage); however, retinal detachment was not identified via histologic examination for 6 of 38 (16%) eyes with that diagnosis determined via ultrasonography at the other facility.
Agreement between tests evaluated in this study was clinically satisfactory for identification of intraocular neoplasia. Typically, diseases were misdiagnosed via ultrasonography for eyes with poor image contrast. Because determination of ultrasonographic diagnoses of retinal detachment and intraocular neoplasm may be of prognostic importance, performance of additional ultrasonographic techniques may be indicated.
比较患有眼部疾病动物眼睛的超声检查和组织学检查结果。
回顾性病例系列研究。
在2个机构检查的113只动物的116只眼睛。
对患病动物的眼睛进行超声检查，通过眼球摘除术或眼眶内容剜除术取出，然后进行组织学检查。评估超声图像和组织病理学切片，并通过这两种方法识别眼部疾病并分类。对于每个疾病类别，通过确定κ统计值评估超声检查结果与组织学检查结果之间的一致性。
在识别虹膜或睫状体肿瘤方面，两种检查具有良好的一致性。总体而言，在31只经组织学检查发现肿瘤的眼睛中，只有2只通过超声检查未检测到眼内肿瘤。在37只眼睛中有8只（22%）的出血性或炎症性改变被误诊为肿瘤。在识别视网膜脱离方面，两种检查具有中度至可接受的一致性。在其中一个机构通过组织学检查确诊为视网膜脱离的38只眼睛中，有14只（37%）通过超声检查未检测到视网膜脱离（主要是眼内出血的眼睛）；然而，在另一个机构通过超声检查确诊为视网膜脱离的38只眼睛中，有6只（16%）通过组织学检查未识别出视网膜脱离。
本研究中评估的两种检查之间的一致性在临床上对于识别眼内肿瘤是令人满意的。通常，对于图像对比度差的眼睛，超声检查会出现误诊。由于视网膜脱离和眼内肿瘤的超声诊断对于预后可能具有重要意义，可能需要采用额外的超声检查技术。
