Department of Chemistry, University of Miami, Coral Gables, Florida 33146, USA.
J Am Chem Soc. 2013 Jul 31;135(30):11048-54. doi: 10.1021/ja402215t. Epub 2013 Jul 18.
Peptide-based methods represent new approaches to selectively produce nanostructures with potentially important functionality. Unfortunately, biocombinatorial methods can only select peptides with target affinity and not for the properties of the final material. In this work, we present evidence to demonstrate that materials-directing peptides can be controllably modified to substantially enhance particle functionality without significantly altering nanostructural morphology. To this end, modification of selected residues to vary the site-specific binding strength and biological recognition can be employed to increase the catalytic efficiency of peptide-capped Pd nanoparticles. These results represent a step toward the de novo design of materials-directing peptides that control nanoparticle structure/function relationships.
基于肽的方法代表了选择性地生产具有潜在重要功能的纳米结构的新方法。不幸的是，生物组合方法只能选择具有目标亲和力的肽，而不能选择最终材料的性质。在这项工作中，我们提供了证据来证明，可以对材料导向肽进行可控修饰，在不显著改变纳米结构形态的情况下，显著提高颗粒的功能。为此，可以通过修饰选定的残基来改变特定位置的结合强度和生物识别，从而提高肽封端的钯纳米颗粒的催化效率。这些结果代表了朝着从头设计控制纳米颗粒结构/功能关系的材料导向肽迈出的一步。
