Smith T, Jakobsen J, Trojaborg W
Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark.
AIDS. 1990 Jun;4(6):589-91. doi: 10.1097/00002030-199006000-00017.
The clinical significance of myelopathy associated with HIV infection is poorly understood. Recently, a prospective electrophysiological follow-up study of spinal-evoked potentials in HIV-seropositive men without AIDS revealed a 32% prolongation of the latency from the gluteal crease to the 12th thoracic vertebra (T12) following tibial nerve stimulation at the ankle performed after an interval of 2 years. In AIDS patients this transmission delay did not increase further. Instead, the latency prolongation took place proximal to T12. We assume that myelopathy is an integral part of HIV infection that it is asymptomatic in the early disease phase, spreads from the lumbar part the spinal cord in a rostral direction and leads to the development of leg weakness and ataxia during the later stages of the disease.
与HIV感染相关的脊髓病的临床意义尚不清楚。最近，一项针对未患艾滋病的HIV血清阳性男性的脊髓诱发电位的前瞻性电生理随访研究显示，在间隔2年后于脚踝处进行胫神经刺激后，从臀横纹到第12胸椎（T12）的潜伏期延长了32%。在艾滋病患者中，这种传导延迟没有进一步增加。相反，潜伏期延长发生在T12近端。我们认为脊髓病是HIV感染的一个组成部分，在疾病早期无症状，从脊髓腰部向头侧扩散，并在疾病后期导致腿部无力和共济失调。
